L. R. Tranquill
National Institutes of Health
17 Papers
153 Citations
L. R. Tranquill is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Myelin basic protein & T cell. The author has an hindex of 16, co-authored 17 publications.
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Papers
Mechanisms of immunomodulation by glatiramer acetate.
Bruno Gran,L. R. Tranquill,M. Chen,Bibiana Bielekova,W. Zhou,Suhayl Dhib-Jalbut,Roland Martin +6 more
TL;DR: This study confirms a preferential inhibitory effect of GA on autoreactive TCC and demonstrates further that GA induces T cells that crossreact with myelin proteins that play an important role in mediating the effect of the drug in vivo.
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Phase 1 trial of transforming growth factor beta 2 in chronic progressive MS
P. A. Calabresi,N. S. Fields,H. Maloni,A. Hanham,J. Carlino,J. Moore,Michael C. Levin,Suhayl Dhib-Jalbut,L. R. Tranquill,Howard A. Austin,Henry F. McFarland,Michael K. Racke +11 more
TL;DR: Systemic TGF-β2 may be associated with reversible nephrotoxicity, and further investigation of its therapeutic potential in MS should be performed with caution.
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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.
Paolo A. Muraro,Marco Vergelli,M. Kalbus,Darhlene E. Banks,James W. Nagle,L. R. Tranquill,Gerald T. Nepom,William E. Biddison,Henry F. McFarland,Roland Martin +9 more
TL;DR: New insight is provided about MBP recognition and an alternative mechanism for immunodominance of self-antigen T cell epitopes in humans is proposed, suggesting that only high affinity T cell receptors might be able to efficiently engage such unstable MHC/peptide complexes.
•Journal Article
Human autoreactive cd4+ t cell clones use perforin- or fas/fas ligand-mediated pathways for target cell lysis
Marco Vergelli,Bernhard Hemmer,Paolo A. Muraro,L. R. Tranquill,William E. Biddison,Apurva Sarin,Henry F. McFarland,Roland Martin +7 more
TL;DR: It is shown that individual T cell clones, regardless of their cytokine phenotype, can be noncytotoxic or lyse target cells via either perforin- or Fas/Fas ligand-mediated cytotoxicity.
108
Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87–99)
Marco Vergelli,Bernhard Hemmer,Ursula Utz,Anne B. Vogt,M. Kalbus,L. R. Tranquill,Paul J. Conlon,Nicholas Ling,Lawrence Steinman,Henry F. McFarland,Roland Martin,Roland Martin +11 more
TL;DR: It is shown that neutral (L‐alanine substitutions) or conservative exchanges of the primary and secondary TCR contact residues lead to various alterations of T cell function, ranging from differences in interleukin‐2 receptor up‐regulation to anergy induction and TCR antagonism.
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