9 Papers
25 Citations
L Li is an academic researcher from Stanford University. The author has contributed to research in topics: Astrocyte & Hippocampal formation. The author has an hindex of 4, co-authored 7 publications.
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Papers
Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-α☆
Creed M. Stary,Lijun Xu,L Li,Xiaoyun Sun,Yi-Bing Ouyang,Xiaoxing Xiong,Jing Zhao,Rona G. Giffard +7 more
TL;DR: The results of the present study suggest miR‐181a inhibition enhances E2‐mediated stroke protection in females in part by augmenting ER&agr; production, a mechanism detected in female mice and female astrocytes.
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miR-29a differentially regulates cell survival in astrocytes from cornu ammonis 1 and dentate gyrus by targeting VDAC1.
TL;DR: The findings suggest that the selective vulnerability of the CA1 to injury may be due in part to a limited miR-29a response in CA1 astrocytes, allowing a greater increase in VDAC1-mediated cellular dysfunction in CA2 astroCytes.
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Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs
L Li,Creed M. Stary +1 more
TL;DR: The role that astrocytes and microglia play in neuronal function and fate following ischemic stress is reviewed, the relevance of mitochondria in the glial response to injury is discussed, and current evidence implicating miR-targeted therapies represent a viable intervention to optimize glial mitochondrial function and improve clinical outcome following cerebral ischemia is presented.
High-Resolution MRI for Evaluation of the Possibility of Successful Recanalization in Symptomatic Chronic ICA Occlusion: A Retrospective Study
Min Tang,X. Yan,J. Gao,L Li,Xia Zhe,Xin Zhang,Feng Jiang,J. J. Hu,N. Ma,Kai Ai,Xiaoling Zhang +10 more
TL;DR: In symptomatic chronic ICA occlusion, lesion length and calcification volume, the level of reversed distal ICA flow, and the lumen area appear to be predictors of successful recanalization.
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Central Neuroinflammation in Cerebral Ischemia: The Role of Glia
TL;DR: In this paper, the critical role that microglia and astrocytes play in the induction of poststroke neuroinflammation, and their potential as targets in the next generation of therapeutic strategies for thrombotic stroke was discussed.
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