There are limited data on vascular, inflammatory, metabolic risk factors of dementia in Parkinson's disease (PD) with type 2 diabetes mellitus (DM) (PD-DM). In a study of 928 subjects comprising of 215 PD with DM (including 31 PD-DM with dementia, PD-DMD), 341 PD without DM (including 31 PD with dementia, PDD) and 372 DM without PD (including 35 DM with dementia, DMD) patients, we investigated if vascular, inflammatory, metabolic, and magnetic resonance imaging (MRI) markers were associated with dementia in PD-DM. Lower fasting blood glucose (FBG 15μmol/L, OR=3.131; 95%CI: 1.243-7.888; p=0.015) and hyperlipidemia (OR=3.075; 95%CI: 1.142-8.277; p=0.026), increased age (OR=1.043; 95%CI: 1.003-1.084; p=0.034) were the most significant risk factors in PDD patients. Lower low-density lipoprotein cholesterol (LDL-C 4g/L, OR=4.066; 95%CI: 1.467-11.274; p=0.007) were the most significant risk factors in PD-DMD patients. The area under the curve (AUC) for fibrinogen and LDL-C was 0.717 (P=0.001), with a sensitivity of 80.0% for the prediction of PD-DMD.In summary, we identified several factors including LDL-C and fibrinogen as significant risk factors for PD-DMD and these may have prognostic and treatment implications.

Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson's disease patients with type 2 diabetes mellitus.

Background and objective Prostate cancer (PCa) is one of the most common malignant tumors in men. Geriatric Nutritional Risk Index (GNRI) is an objective index for evaluating nutritional status of elderly people over 65 years old. The aim of the current study was to explore the correlation and predictive value between GNRI and postoperative recovery and complications in PCa patients undergoing laparoscopic radical prostatectomy (LRP). Methods Taking 98 as the GNRI boundary value, 96 PCa patients (aged≥65 y) undergoing LRP in the Department of Urology, Affiliated Hospital of North Sichuan Medical College from January 2018 to December 2020 were grouped into malnutrition group (MNg, 34 patients, 35.4%) and normal nutrition group (NNg, 62 patients, 64.6%). Basic information, laboratory examination indexes, operation conditions, postoperative complications and postoperative recovery indexes of patients were recorded and retrospectively analyzed. Clavien-Dindo Classification System (CDCS) was used to assess postoperative complications. T-test was used to analyze differences between the two groups. ROC curve was generated to determine the predictive value of GNRI for postoperative complications. Results Percentage of complications was significantly higher in MNg group compared with that in NNg group (P < 0.01). The average grade based on CDCS was significantly lower in NNg group compared with that in MNg group (P < 0.01). Body weight, Body Mass Index (BMI), preoperative hemoglobin value (HGB), serum albumin (ALB) values of MNg and NNg were significantly positively correlated with GNRI (P<0.01). Incidence and severity of postoperative complications of MNg patients were significantly higher compared with those of NNg patients (P<0.05). Average hospitalization cost of MNg patients was higher in MNg patients compared with that of NNg patients (P<0.05). Duration of post-anesthesia care unit (PACU), duration of antibiotic use and duration of indwelling drainage tube were longer in MNg patients compared with those in NNg patients (P<0.05). Furthermore, volume of indwelling drainage tube was higher in MNg patients compared with that in NNg patients (P<0.05). Conclusion GNRI is an effective and reliable tool for evaluation of preoperative nutritional status of prostate cancer patients. The findings showed that GNRI is correlated with postoperative recovery and complications, and is an effective predictive marker.

/pdf/preoperative-nutritional-evaluation-of-prostate-cancer-irax1qa2.pdf

Preoperative nutritional evaluation of prostate cancer patients undergoing laparoscopic radical prostatectomy

P140 - La prévalence en 2007 de la dénutrition dans les centres de lutte contre le cancer (CLCC)

INTRODUCTION
the nutritional intervention has become a critical point to achieve the reduction of perioperative morbidity and mortality in cancer patients. There are different factors that will play a fundamental role in the evolution and prognosis of this pathology, being the state of nutrition and diet a cornerstone in these aspects.


OBJECTIVE
to evaluate the perioperative effect of whey protein isolate (WPI) and calcium caseinate (CaCNT) in cancer patients undergoing elective surgery.


METHODS
randomized controlled clinical trial with three groups: the control group (n = 15), consisting in conventional management by the oncology surgery services, and two intervention groups, one with calcium caseinate supplementation (n = 15) and another one with whey protein isolate supplementation (n = 15) for six weeks perioperatively. Handgrip strength, six-minute walk, and body composition were assessed pre and postoperatively.


RESULTS
those who were supplemented with WPI maintained their handgrip strength and showed less extracellular water (p < 0.02); also an increase in visceral mass was shown (p < 0.02). Finally, a correlation was found with variables associated with body composition and patient evolution when compared to the control group.


CONCLUSIONS
nutritional supplementation needs to be approached from the functional and metabolic point of view to identify factors that have a favorable impact, as well as the distinction between carcinoma and the type of supplementation to be implemented.

[Whey protein and caseinate supplementation in oncological patients undergoing elective surgery for the modification of functional capacity].

Zusammenfassung. Das Refeeding-Syndrom ist ein potenziell lebensbedrohlicher Zustand, welcher beim Wiederernähren von mangelnährten Patientinnen und Patienten auftreten kann. In den letzten Jahren wurden von den wichtigen Fachgesellschaften für klinische Ernährung ESPEN und ASPEN zwei Konsensusmanuskripte publiziert. Pathophysiologische Aspekte, klinische Manifestationen, Präventionsmassnahmen sowie Kriterien zur Diagnosestellung und zum Management wurden ausführlich beschrieben. Ziel dieser Mini-Review ist es, einen evidenzbasierten Überblick zum Refeeding-Syndrom zu geben. Zu diesem Zweck wurde die systematische Literatursuche von Friedli et al. 2015 aktualisiert. Es besteht die Evidenz, dass das Refeeding-Syndrom mit einem negativen klinischen Outcome assoziiert ist. Viele Fragen zu Managementaspekten bleiben weiterhin offen. Eine robuste, randomisierte kontrollierte Studie ist dringend notwendig, um diese Fragen evidenzbasiert zu beantworten und zuverlässige Hinweise über unabhängige Prädiktoren sowie eine Abschätzung des metabolischen Risikos zu eruieren.

Refeeding-Syndrom: Wo stehen wir 2022?

Preoperative nutrition forseverely malnourished patients in digestive surgery: A retrospective study.

/pdf/nutrition-preoperatoire-des-patients-severement-denutris-en-3yo01jm1ie.pdf

Nutrition préopératoire des patients sévèrement dénutris en chirurgie digestive : étude rétrospective

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Preoperative nutrition forseverely malnourished patients in digestive surgery: A retrospective study.

Nutrition préopératoire des patients sévèrement dénutris en chirurgie digestive : étude rétrospective