Hürthle Cell Neoplasms of the Thyroid

Neoplastic and non-neoplastic oxyphil cells in thyroid disorders were investigated for enzyme and synthetic activity, ultrastructural features, and immune complex deposition. A reduced but definite content of thyroglobuliin and similar enzyme profiles and ultrastructural features in all types of oxyphill change were found. Immune complex deposition was seen in Graves' disease and Hashimoto's thyroiditis but not in oxyphil neoplasms or colloid goitre with focal oxyphil change. The findings suggest that oxyphil cells do represent a uniform change. Immunological damage with immune complex deposition might be the cause of oxyphil change in only some conditions.

https://jcp.bmj.com/content/jclinpath/39/8/908.full.pdf

Oxyphil cells in thyroid disease: a uniform change?

Antibodies to Cytokeratin 14 Specifically Identify Oncocytes (H??rthle Cells) in Thyroid Lesions and Tumors

Hürthle cell carcinoma of the thyroid presenting as thyrotoxicosis.

Although Hurthle cell tumors are considered to be variants of follicular neoplasms, they have distinct cytologic and behavioral characteristics. To elucidate the basis for these differences, the expression of 5 oncogenes and growth factors (Pan- ras , N- myc , transforming growth factor-α [TGF-α], transforming growth factor-β [TGF-β], and insulin-like growth factor 1 [IGF-1]) was compared between 12 follicular carcinomas and 8 Hurthle cell carcinomas by immunocytochemistry. The percentage of follicular carcinomas and Hurthle cell carcinomas that stained positively for the different oncogenes was as follows and respectively: Pan- ras 8% versus 63%; TGF-α 17% versus 63%; TGF-β 25% versus 88%; IGF-1 17% versus 88%; and N- myc 17% versus 100%. All these differences were highly significant by the X 2 test. This difference in the expression of oncogenes between Hurthle cell carcinomas and follicular carcinomas suggests that these two tumors could, in fact, represent separate entities.

Differential oncogenic expression in thyroid follicular and Hürthle cell carcinomas.

The present study reports the biochemical and immunohistochemical findings in the cytosol of a Hurthle cell carcinoma as compared with that of normal thyroid tissue. Sephadex G-200 chromatography of the extract derived from a Hurthle cell carcinoma and from normal thyroid tissue revealed three identical pools. Pool I consisted mainly of thyroglobulin (Tg), pool II corresponded to albumin, while pool III contained unidentified low molecuar weight fragments which could not be studied further. Hurthle cell carcinoma, pool I, had a Tg content of 12.9 μg Tg/mg equivalent tissue and a 127I content of 5, 6 mole/mole of Tg. Its sialic acid content was undetectable, however. In pool I of the normal thyroid gland, the respective values were 62.8 μg Tg/ mg equivalent tissue, 21.3 mole 127I/mole Tg, and 15.4 mole sialic acid/mole Tg. The albumin contained in both pools II was shown to be ioidinated at the following levels: 0.025 mole 127I/mole albumin in Hurthle tumor pool II vs 1.28 mole 127I/mole albumin in normal thyroid pool II. Immunohistochemical studies confirmed the presence of Tg and albumin in the malignant Hurthle cells and acini and colloid. Thus, Hurthle cell carcinoma contained Tg and albumin. The Tg content was five times less compared with control tissue. Both proteins (Tg and albumin) were poorly iodinated in Hurthle carcinoma tissue, and the iodination of albumina seemed to be more severely impaired. The site of synthesis of both proteins could not be derived from the presejit studies.

Biochemical and immunohistochemical characterization of proteins in Hurthle cell carcinoma

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Biochemical and immunohistochemical characterization of proteins in Hurthle cell carcinoma