7 Papers
28 Citations
L. Lammens is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Gastric emptying & Nose. The author has an hindex of 6, co-authored 7 publications.
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Papers
Gavage-Related Reflux in Rats Identification, Pathogenesis, and Toxicological Implications (Review)
Siegrid Damsch,Gary Eichenbaum,Alfred Tonelli,L. Lammens,Kathleen Van den Bulck,Bianca Feyen,John Vandenberghe,Anton Megens,Elaine Knight,Kelley Michael F +9 more
TL;DR: The article aims to increase the awareness and understanding of the pathogenesis of gavage-related reflux and provides guidance on identification of potential risk factors, as well as interpretation of histological changes and their toxicological relevance.
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Impact of gavage dosing procedure and gastric content on adverse respiratory effects and mortality in rat toxicity studies
Gary Eichenbaum,Siegrid Damsch,Adriana Looszova,John Vandenberghe,K. Van den Bulck,Karen Roels,Anton Megens,Elaine Knight,V. Hillsamer,Bianca Feyen,Kelley Michael F,Alfred Tonelli,L. Lammens +12 more
TL;DR: Reducing the dose volume and dosing fasted animals substantially reduced or eliminated the respiratory effects and mortality at the high test article concentrations, demonstrating that the adverse effects are related to the gavage method.
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Real life juvenile toxicity case studies: The good, the bad and the ugly
Luc De Schaepdrijver,Marie-Claude Rouan,Araz Raoof,Graham P. Bailey,Loeckie de Zwart,Johan Monbaliu,Timothy P. Coogan,L. Lammens,Werner Coussement +8 more
TL;DR: Only when using the appropriate strategy and design may juvenile studies add value by identifying potential safety or pharmacokinetic issues for drugs intended for paediatric use, suggesting additional clinical endpoints and adding new information to the product label.
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Unexpected Nasal Changes in Rats Related to Reflux after Gavage Dosing
Siegrid Damsch,Gary Eichenbaum,Adriana Looszova,L. Lammens,Bianca Feyen,Kathleen Van den Bulck,Elaine Knight,Kelley Michael F,Alfred Tonelli +8 more
TL;DR: The current article focuses on the histological changes in the nasal cavity indicative of gavage-related reflux and provides guidance on differentiation between technical gavage error and g Savage- related reflux.
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Miscellaneous: P17: Lethal rhinitis/sinusitis in rodents by aspiration of formulation in gavage studies: Importance of evaluation of the nose
S. De Jonghe,L. Lammens,A. Raoof,K. Steemans,F. Broeckaert,Johan Verbeeck,F. Van Goethem,G. Hanton +7 more
TL;DR: Evaluating the nose can be valuable to determine the cause of death in rodents and resulted in entry of the formulation in the respiratory tract with subsequent inflammatory/necrotizing changes.
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