L. Kunze
15 Papers
9 Citations
L. Kunze is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 12 publications.
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Papers
A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models
Bettina van Lengerich,Lihong Zhan,Dan Xia,Darren K.W. Chan,David A Joy,Joshua I. Park,David Tatarakis,Meredith E. K. Calvert,Selina Hummel,Steve Lianoglou,Michelle E. Pizzo,Rachel Prorok,Elliot R. Thomsen,L. Bartos,Philipp Beumers,Anja Capell,Sonnet S. Davis,Lis de Weerd,Jason C. Dugas,Joseph N. Duque,Timothy K. Earr,Kapil Gadkar,Tina Giese,Audrey Gill,Johannes Gnörich,Connie Ha,Malavika Kannuswamy,Do Jin Kim,Sebastian T Kunte,L. Kunze,Diana Lac,Kendra J. Lechtenberg,Amy Wing-Sze Leung,Chun-Chi Liang,Isabel Lopez,Paul V. McQuade,Anuja Modi,Vanessa O Torres,Hoang Nguyen,Ida Pesämaa,Nicholas E. Propson,Marvin Reich,Yaneth Robles-Colmenares,Kai Schlepckow,L. Slemann,Hilda Solanoy,Jung H. Suh,Robert G. Thorne,Chandler Vieira,Karin Wind-Mark,Ken Xiong,Y. Joy Yu Zuchero,Dolo Diaz,Mark S. Dennis,Fen Huang,Kimberly Scearce-Levie,Ryan J. Watts,Christian Haass,Joseph W. Lewcock,Gilbert Di Paolo,Matthias Brendel,Pascal E. Sanchez,Kathryn M. Monroe +62 more
TL;DR: A high affinity human TREM2-activating antibody engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody transport vehicle (ATV), was used to facilitate blood-brain barrier transcytosis as mentioned in this paper .
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia,Steve Lianoglou,Thomas Sandmann,Meredith E. K. Calvert,Jung H. Suh,Elliot R. Thomsen,Jason C. Dugas,Michelle E. Pizzo,Sarah Lorraine DeVos,Timothy K. Earr,Chia Ching Lin,Sonnet S. Davis,Connie Ha,Amy Wing-Sze Leung,Hoang Nguyen,Roni Chau,Ernie Yulyaningsih,Isabel Lopez,Hilda Solanoy,Shababa T. Masoud,Chun-Chi Liang,Karin Lin,Giuseppe Astarita,Nathalie Khoury,Joy Yu Zuchero,Robert G. Thorne,Kevin Shen,S. Miller,Jorge J. Palop,Dylan Garceau,Michael Sasner,Jennifer D. Whitesell,Julie A. Harris,Selina Hummel,Johannes Gnörich,Karin Wind,L. Kunze,A.V Zatcepin,Matthias Brendel,Michael Willem,Christian Haass,Daniel H. Barnett,Till Zimmer,Anna G. Orr,Kimberly Scearce-Levie,Joseph W. Lewcock,Gilbert Di Paolo,Pascal E. Sanchez +47 more
TL;DR: In this article , the authors used in situ imaging technologies to define the whole-brain distribution of amyloid plaques and compare it to other AD mouse models and human brain pathology.
Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia
Dan Xia,Steve Lianoglou,Thomas Sandmann,Meredith E. K. Calvert,Jung H. Suh,Elliot R. Thomsen,Jason C. Dugas,Michelle E. Pizzo,Sarah Lorraine DeVos,Timothy K. Earr,Chia Ching Lin,Sonnet S. Davis,Connie Ha,Amy Wing-Sze Leung,Hoang Nguyen,Roni Chau,Ernie Yulyaningsih,Isabel Lopez,Hilda Solanoy,Shababa T. Masoud,Chun-Chi Liang,Karin Lin,Giuseppe Astarita,Nathalie Khoury,Joy Yu Zuchero,Robert G. Thorne,Kevin Shen,S. Miller,Jorge J. Palop,Dylan Garceau,Michael Sasner,Jennifer D. Whitesell,Julie A. Harris,Selina Hummel,Johannes Gnörich,Karin Wind,L. Kunze,A.V Zatcepin,Matthias Brendel,Michael Willem,Christian Haass,Daniel H. Barnett,Till Zimmer,Anna G. Orr,Kimberly Scearce-Levie,Joseph W. Lewcock,Gilbert Di Paolo,Pascal E. Sanchez +47 more
TL;DR: In this article , the authors used in situ imaging technologies to define the whole-brain distribution of amyloid plaques and compare it to other AD mouse models and human brain pathology.
18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model
L. Bartos,S V Kirchleitner,Jens Blobner,Karin Wind,L. Kunze,Adrien Holzgreve,L. Gold,A.V Zatcepin,Z. I. Kolabas,Selin Ulukaya,Lorraine Weidner,S. Quach,Denise Messerer,Peter Bartenstein,Jörg C. Tonn,Markus J. Riemenschneider,Sibylle Ziegler,Louisa von Baumgarten,Nathalie L. Albert,Matthias Brendel +19 more
TL;DR: TSPO-PET imaging of immunocompetent SB28 mice facilitates early detection of tumor signals over sham lesions and could serve as a valuable translational model to study TSPO as an imaging biomarker.
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution
L. Bartos,S V Kirchleitner,Z. I. Kolabas,S. Quach,Jens Blobner,Stephan A Mueller,Selin Ulukaya,Luciano Hoeher,Izabela Horvath,Karin Wind-Mark,Adrien Holzgreve,Viktoria Ruf,L. Gold,L. Kunze,Sebastian T Kunte,Philipp Beumers,M. Antons,A.V Zatcepin,Nils Briel,Leonie Hoermann,Denise Messerer,Peter Bartenstein,Markus J. Riemenschneider,Simon Lindner,Sibylle Ziegler,Jochen Herms,Stefan F. Lichtenthaler,Ali Ertürk,Jörg C. Tonn,Louisa von Baumgarten,Nathalie L. Albert,Matthias Brendel +31 more
TL;DR: In this paper , the authors developed immunomagnetic cell sorting after in vivo radiotracer injection (scRadiotracing) in combination with 3D-histology via tissue clearing to dissect the cellular allocation of PET signals in the tumor microenvironment.
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