Understanding asthma-chronic obstructive pulmonary disease overlap syndrome

Rationale 

Current therapeutic options fail to prevent or reverse irreversible obstruction in some patients with asthma. Careful phenotyping will allow more detailed understanding of the underlying pathophysiology, such as the accompanying inflammatory pathways. This can promote the development of targeted prophylaxis or treatment.

Aim 

To examine whether fixed airways obstruction in patients with asthma is associated with markers of airway inflammation, FeNO, total IgE, and BMI.

Methods 

This was a cross-sectional analysis of the U-BIOPRED cohort. Severe asthma was defined by the IMI-criteria (Bel et al . Thorax 2011). Patients with mild/moderate asthma used ICS (≤500mcg FP), were (partly) controlled according to GINA-criteria, and were (ex)non-smokers (≤5 py). Fixed airways obstruction was defined as a postbronchodilator FEV1 or FEV1/FVC 75% predicted. Wilcoxon rank sum test was used to test for associating factors.

Results 

Data were available for 148 patients, of which 118 with severe asthma. Persistent airflow limitation was observed in 46% of the patients and was significantly associated with sputum eosinophils (Sp.eos.), sputum alveolar macrophages (Sp.alv.macroph.) and age (Table 1).

View this table:

Table 1





Conclusion 

This preliminary analysis of the U-BIOPRED cohort shows that fixed airflow limitation in asthma is associated with elevated sputum eosinophils and lower sputum alveolar macrophages, suggesting a distinguishable inflammatory profile in the airways.

https://erj.ersjournals.com/content/erj/42/Suppl_57/P3142.full.pdf

Associated factors with persistent airflow limitation in asthma in U-BIOPRED

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

L. Jeyasingham

Author Tools

Chat about Author

Papers

Associated factors with persistent airflow limitation in asthma in U-BIOPRED