L. Hou
2 Papers
2 Citations
L. Hou is an academic researcher. The author has contributed to research in topics: Internal medicine & Haplogroup. The author has an hindex of 1, co-authored 1 publications.
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Papers
The association between mitochondrial DNA copy number, low-density lipoprotein cholesterol, and cardiovascular disease risk
X L Liu,X. Sun,Y Zhang,Ming May Lai,Kerri L. Wiggins,L. Raffield,Lawrence F. Bielak,Wei Zhao,Achilleas N. Pitsillides,Jeffrey Haessler,Yu Zheng,Thomas W. Blackwell,J. Yao,Xu Guo,Yafang Qian,Bharat Thyagarajan,Nathan Pankratz,Steve Rich,Kent D. Taylor,Patricia A. Peyser,S. Heckbert,Sudha Seshadri,Eric Boerwinkle,M. Grove,Nicholas B. Larson,J. Smith,Vinitha Ramachandran,A. Fitzpatrick,Myriam Fornage,Jun Ding,April P. Carson,G. Abecasis,Josée Dupuis,Alexander P. Reiner,Charles Kooperberg,L. Hou,B. M. Psaty,J. S. Wilson,Daniel Levy,J. Rotter,J. C. Bis,Claudia L. Satizabal,D. Arking,C. Liu +43 more
TL;DR: High LDL underlies the complex relationships between vascular atherosclerosis and lower mtDNA CN, and finds no evidence supporting a causal association for lower mt DNA CN with higher CHD risk or higher LDL, but bi-directional univariable and multivariable MR analyses provided strong evidence indicating higher LDL level is causally associated with lower mitochondrial DNA copy number, and CHD was weakly associated with higher mtDNACN.