The intravenous administration of 50 mg of lidocaine as a single bolus to four patients with heart disease did not result in a significant change in cardiac output or left ventricular end-diastolic pressure (LVEDP). Two patients had moderate decrease in systemic arterial pressure which was not accompanied by symptoms, was of short duration, and did not require therapeutic intervention. Left ventricular function, as assessed by the relationship of changes in stroke volume index (SVI) and stroke work index (SWI) to changes in LVEDP, was not significantly affected nor was the maximum rate of rise of left ventricular pressure (dp/dt). The intravenous injection of 100 mg of lidocaine into eight additional patients with heart disease did not produce a statistically significant change in any of these hemodynamic variables when compared to their respective control values. Examination of individual responses, however, revealed that some depression of left ventricular function occurred in at least three and probabl...

Hemodynamic effects of lidocaine in patients with heart disease

Twenty patients with ventricular arrhythmias were treated with procaine amide to determine an antiarrhythmic plasma drug concentration range and to observe procaine amide's effect on blood...

Intermittent Intravenous Procaine Amide to Treat Ventricular Arrhythmias

In the anesthetized dog, the intravenous injection of quinidine consistently induces a fall in systemic blood pressure hut a biphasic rise and fall in pulmonary arterial pressure. The femoral and pulmonary blood vessels are dilated but the heart is initially stimulated and depressed. All these effects are manifestations of local actions of quinidine on the heart and blood vessels, except the cardiac stimulation. Like quinidine, procainamide dilates the pulmonary and femoral blood vessels and depresses the heart. Unlike quinidine, procainamide induces a pure fall in pulmonary arterial pressure.

The cardiopulmonary effects of quinidine and procainamide

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The cardiopulmonary effects of quinidine and procainamide