Dysregulation of Met signaling has been implicated in the initiation, progression and metastasis of human cancers, and therefore represents an attractive target for anticancer drug development. Met is overexpressed in non-small-cell lung cancer and its lack of staining in normal lung tissue makes it an attractive target. To date, erlotinib and gefitinib have established themselves as first-line therapy for non-small-cell lung cancer patients whose tumors harbor an EGF receptor gene mutation, and hence, it is crucial that we identify mechanisms of resistance that could be targeted by novel agents, while keeping an acceptable toxicity profile at the same time; something very important when we develop these new drugs. Inhibitors of the Met pathway represent a therapeutic alternative in this setting. In this review, we discuss the early clinical studies reported using two Met inhibitors, a monoclonal antibody (MetMAb) and a small molecule tyrosine kinase inhibitor (MGCD265).

Targeting the Met pathway in lung cancer.

The Importance of Molecular Profiling in Predicting Response to Epidermal Growth Factor Receptor Family Inhibitors in Non–Small-Cell Lung Cancer: Focus on Clinical Trial Results

Provided herein are pharmaceutical formulations comprising a one-armed, anti-c-met antibody and uses of the same.

Anti-c-met-antibody formulations

Many data are presented each year during the American Society of Clinical Oncology meeting, redrawing the state of knowledge in oncology and hematology. This article proposed by the editorial board of the Bulletin du Cancer proposes to discuss new information with a drop of a few months with the aim of trying to identify the results that can have an immediate or future impact on clinical practice.

Les données incontournables du congrès de l'American Society of Clinical Oncology (Asco) 2011 : le point de vue du comité de rédaction du Bulletin du Cancer

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

Cancer treatment with c-met antagonists and correlation of the latter with hgf expression

7604 Background: MetMAb (M) is a monovalent monoclonal antibody that blocks HGF-induced Met signaling. A Phase II double-blinded, randomized trial of MetMAb+erlotinib (M+E) or placebo+erlotinib (P+E) in 2nd- and /3rd- line NSCLC was recently completed. The M+E arm demonstrated both PFS and OS advantages in the c-Met IHC expression positive 2+ /3+ (Met Dx+) patients only. Methods: Adverse events (AEs) were assessed for MetMAb related toxicities. In addition to AEs, tumor growth rate and onset of new lesions were evaluated to understand their potential contribution to the clinical outcomes. Results: In the M+E arm, median cycles of M were higher in Met Dx+ vs. Met Dx- pts (4 vs. 2) as were median E doses (61 vs. 42 respectively). Overall pattern of AEs were similar in the two treatment arms, with the exception of peripheral edema which was higher on M+E; regardless of c-Met expression levels. Time to onset of any Grade ≥3 AE in M+E treated patients was also similar across groups. In the Met Dx- group, Grade...

Safety data and patterns of progression in met diagnostic subgroups in OAM4558g; A phase II trial evaluating MetMAb in combination with erlotinib in advanced NSCLC.

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Safety data and patterns of progression in met diagnostic subgroups in OAM4558g; A phase II trial evaluating MetMAb in combination with erlotinib in advanced NSCLC.