Protecting the infant through nutrition – are prebiotics the answer?

The pH-related metabolic paradigm has rapidly grown in cancer research and treatment. In this contribution, this recent oncological perspective has been laterally assessed for the first time in order to integrate neurodegeneration within the energetics of the cancer acid–base conceptual frame. At all levels of study (molecular, biochemical, metabolic, and clinical), the intimate nature of both processes appears to consist of opposite mechanisms occurring at the far ends of a physiopathological intracellular pH/extracellular pH (pHi/pHe) spectrum. This wide-ranging original approach now permits an increase in our understanding of these opposite processes, cancer and neurodegeneration, and, as a consequence, allows us to propose new avenues of treatment based upon the intracellular and microenvironmental hydrogen ion dynamics regulating and deregulating the biochemistry and metabolism of both cancer and neural cells. Under the same perspective, the etiopathogenesis and special characteristics of multiple sclerosis (MS) is an excellent model for the study of neurodegenerative diseases and, utilizing this pioneering approach, we find that MS appears to be a metabolic disease even before an autoimmune one. Furthermore, within this paradigm, several important aspects of MS, from mitochondrial failure to microbiota functional abnormalities, are analyzed in depth. Finally, and for the first time, a new and integrated model of treatment for MS can now be advanced.

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Hydrogen Ion Dynamics as the Fundamental Link between Neurodegenerative Diseases and Cancer: Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis on Multiple Sclerosis

Effects of the immune system on metabolism: implications for production and disease resistance in livestock

Die Darmflora ist fur eine normale Entwicklung des menschlichen Immunsystems notwendig, und zwar sowohl in bezug auf seine Fahigkeit, mit Abwehr zu antworten, als auch seine Fahigkeit, immunologische Toleranz zu entwickeln, hauptsachlich via Darmmukosa, d.h. orale Toleranz. Toleranz ist im wesentlichen ein aktiver Prozes, ohne den wir hochstwahrscheinlich eine fortwahrende immunologische-entzundliche Reaktivitat an der Mukosa hatten. Anscheinend entwickeln wir normalerweise eine Toleranz gegen unsere eigene Flora. Die Zerstorung dieser Toleranz konnte bei der Pathogenese entzundlicher Darmerkrankungen eine Rolle spielen.

Immune effects of the normal gut flora

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Immune effects of the normal gut flora