Kyrie Pappas
Icahn School of Medicine at Mount Sinai
8 Papers
Kyrie Pappas is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Biology & PTEN. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Kyrie Pappas include Columbia University & Columbia University Medical Center.
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Papers
A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Benjamin D. Hopkins,Barry Fine,Nicole Steinbach,Nicole Steinbach,Meaghan Dendy,Zachary Rapp,Jacquelyn Shaw,Jacquelyn Shaw,Kyrie Pappas,Kyrie Pappas,Jennifer S. Yu,Cindy Hodakoski,Sarah M. Mense,Joshua U. Klein,Joshua U. Klein,Sarah Pegno,Maria Luisa Sulis,Maria Luisa Sulis,Hannah E. Goldstein,Hannah E. Goldstein,Benjamin Amendolara,Benjamin Amendolara,Liang Lei,Liang Lei,Matthew Maurer,Matthew Maurer,Jeffrey N. Bruce,Peter Canoll,Peter Canoll,Hanina Hibshoosh,Hanina Hibshoosh,Ramon Parsons +31 more
TL;DR: A 576–amino acid translational variant of PTEN, termed PTEN-Long, that arises from an alternative translation start site 519 base pairs upstream of the ATG initiation sequence, adding 173 N-terminal amino acids to the normal PTEN open reading frame may have therapeutic uses.
p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes
Kyrie Pappas,Kyrie Pappas,Jia Xu,Sakellarios Zairis,Lois Resnick-Silverman,Francesco Abate,Nicole Steinbach,Nicole Steinbach,Sait Ozturk,Lao H. Saal,Tao Su,Pamela Cheung,Hank Schmidt,Hank Schmidt,Stuart A. Aaronson,Hanina Hibshoosh,James J. Manfredi,Raul Rabadan,Ramon Parsons +18 more
TL;DR: It is found that wild-type but not mutant p53 binds and activates numerous tumor suppressor genes, including PTEN, STK11(LKB1), miR-34a, KDM6A(UTX), FOXO1, PHLDA3, and TNFRSF10B through consensus binding sites in enhancers and promoters.
Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells.
Hainan Chen,Jeffrey W. Kleinberger,Karen K. Takane,Fatimah Salim,Nathalie Fiaschi-Taesch,Kyrie Pappas,Ramon Parsons,Jing Jiang,Yue Zhang,Hongtao Liu,Peng Wang,Aaron Bender,Stuart J. Frank,Andrew F. Stewart +13 more
TL;DR: The findings show that human β-cells fail to proliferate in response to PRL for multiple reasons, one of which is a paucity of functional PRL receptors, and that murine Stat5 overexpression is able to bypass these impediments.
Allosteric interactions prime androgen receptor dimerization and activation
Elizabeth V. Wasmuth,Arnaud Van Den Broeck,Justin R. LaClair,Elizabeth Hoover,K. E. Lawrence,Navid Paknejad,Kyrie Pappas,Doreen Matthies,Biran Wang,Weiran Feng,Philip A. Watson,John C. Zinder,Wouter R. Karthaus,Michael Jason de la Cruz,Richard K Hite,Katia Manova-Todorova,Zhiheng Yu,Susan T. Weintraub,Sebastian Klinge,Charles L. Sawyers +19 more
TL;DR: In this paper , the androgen receptor (AR) is shown to form a non-obligate dimer with the buried dimer interface utilized by ancestral steroid receptors repurposed to facilitate cooperative DNA binding.
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NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer.
Kyrie Pappas,Tiphaine Martin,Andrew Wolfe,Andrew Wolfe,Christie B. Nguyen,Tao Su,Jian Jin,Hanina Hibshoosh,Ramon Parsons +8 more
- 09 Mar 2021
TL;DR: In this article, the authors show that PTEN expression is decreased and the PRC2-associated methyltransferase EZH2 is increased when compared to adjacent normal ducts.