Kyoichi Ono
Akita University
77 Papers
576 Citations
Kyoichi Ono is an academic researcher from Akita University. The author has contributed to research in topics: Patch clamp & Chemistry. The author has an hindex of 21, co-authored 76 publications.
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Papers
Upregulation of TRPC1 in the development of cardiac hypertrophy.
Takayoshi Ohba,Hiroyuki Watanabe,Manabu Murakami,Yoichiro Takahashi,Kenji Iino,Sadao Kuromitsu,Yasuo Mori,Kyoichi Ono,Toshihiko Iijima,Hiroshi Ito +9 more
TL;DR: TRPC1 functions in Ca(2+) influx, and its upregulation is involved in the development of cardiachypertrophy; moreover, it plays an important role in the regulation of the signaling pathways that govern cardiac hypertrophy.
203
Role of Individual Ionic Current Systems in Ventricular Cells Hypothesized by a Model Study
TL;DR: The gating model of Shirokov et al. is used for both the fast Na+ and L-type Ca2+ channels and serves as a predictive tool in generating testable hypotheses.
186
Effects of PFOS and PFOA on L-type Ca2+ currents in guinea-pig ventricular myocytes.
TL;DR: This work investigates the effects of PFOS and PFOA on action potentials and L-type Ca(2+) currents, I(CaL), in isolated guinea-pig ventricular myocytes using whole-cell patch-clamp recording to provide further insights into the mechanisms of P FOA and PFOS toxicities.
115
Involvement of transient receptor potential canonical 1 (TRPC1) in angiotensin II-induced vascular smooth muscle cell hypertrophy.
Yoichiro Takahashi,Hiroyuki Watanabe,Manabu Murakami,Takayoshi Ohba,Milena Radovanovic,Kyoichi Ono,Toshihiko Iijima,Hiroshi Ito +7 more
TL;DR: The data suggest that Ang II and subsequent NF-kappaB activation induces hCASMC hypertrophy through an enhancement of TRPC1 expression.
82
Role of individual ionic current systems in the SA node hypothesized by a model study.
TL;DR: The model successfully reconstructs the experimental action potentials at various concentrations of external Ca2+ and K+ and demonstrates the unique role of individual voltage- and time-dependent ion channels.
79