Kyle Ware
Ohio State University
17 Papers
124 Citations
Kyle Ware is an academic researcher from Ohio State University. The author has contributed to research in topics: Warfarin & Kidney disease. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Kyle Ware include The Ohio State University Wexner Medical Center.
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Papers
Warfarin-Related Nephropathy Modeled by Nephron Reduction and Excessive Anticoagulation
Kyle Ware,Polina Brodsky,Anjali A. Satoskar,Tibor Nadasdy,Gyongyi Nadasdy,Haifeng Wu,Brad H. Rovin,Udayan Bhatt,Jon Von Visger,Lee A. Hebert,Sergey V. Brodsky +10 more
TL;DR: An animal model of this acute kidney injury based on the 5/6-nephrectomy model combined with excessive anticoagulation may be a useful tool to study the pathogenesis of warfarin-related nephropathy.
5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy.
A. Ozcan,Kyle Ware,Edward Calomeni,Tibor Nadasdy,R. Forbes,Anjali A. Satoskar,Gyongyi Nadasdy,Brad H. Rovin,Lee A. Hebert,Sergey V. Brodsky +9 more
TL;DR: The 5/6NE model of CKD is an appropriate animal model to study the pathogenesis of Warfarin-related nephropathy, and the pharmacokinetics of warfarin is better suited to the study of WRN than that of brodifacoum.
N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy
Kyle Ware,Zahida Qamri,Ayhan Ozcan,Ayhan Ozcan,Anjali A. Satoskar,Gyongyi Nadasdy,Brad H. Rovin,Lee A. Hebert,Tibor Nadasdy,Sergey V. Brodsky +9 more
TL;DR: Glomerular hematuria is a necessary but not sufficient explanation for the AKI in WRN, and the NAC regimen used in the WRN model preserved kidney function in the ischemia-reperfusion model.
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The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures
Douglas L. Feinstein,Douglas L. Feinstein,Belinda S. Akpa,Manuela A.A. Ayee,Anne I. Boullerne,Anne I. Boullerne,David Braun,Sergey V. Brodsky,David Gidalevitz,Zane Hauck,Sergey Kalinin,Kathy Kowal,Ivan Kuzmenko,Kinga Lis,Natalia Marangoni,Michael W. Martynowycz,Michael W. Martynowycz,Israel Rubinstein,Richard B. van Breemen,Kyle Ware,Guy L. Weinberg,Guy L. Weinberg +21 more
TL;DR: Superwarfarins were developed following the emergence of warfarin resistance in rodents as discussed by the authors, and they have a longer half-life and stronger affinity to vitamin K epoxide reductase.
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Oral warfarin and the thrombin inhibitor dabigatran increase blood pressure in rats: hidden danger of anticoagulants?
Kyle Ware,Jay C Vance,Navin Muni,Lee A. Hebert,Anjali A. Satoskar,Gyongyi Nadasdy,Iouri Ivanov,Tibor Nadasdy,Brad H. Rovin,Sergey V. Brodsky +9 more
TL;DR: Both warfarin and dabigatran increase systolic BP in rats, and the data suggest that it is related to decreased thrombin activity associated with anticoagulant treatment.
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