Kyle Trudeau
Boston University
27 Papers
33 Citations
Kyle Trudeau is an academic researcher from Boston University. The author has contributed to research in topics: Mitochondrion & Retinal. The author has an hindex of 16, co-authored 27 publications. Previous affiliations of Kyle Trudeau include Boston Medical Center.
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Papers
Murine Mesenchymal Stem Cell Commitment to Differentiation Is Regulated by Mitochondrial Dynamics.
TL;DR: It is found that mitochondrial morphology and its regulating processes of fission/fusion are modulated early on during commitment, leading to alterations in the bioenergetic profile that are important for differentiation.
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Vascular basement membrane thickening in diabetic retinopathy.
TL;DR: An overview of the current understanding of the BM structure and function is presented, and focuses on how capillary BM thickening develops, its effect on retinal vascular function, and potential strategies for preventing the development of BM Thickening in diabetic retinopathy.
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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain‐mediated cardiotoxicity
Jian Guan,Shikha Mishra,Yiling Qiu,Jianru Shi,Kyle Trudeau,Guy Las,Marc Liesa,Orian S. Shirihai,Lawreen H. Connors,David C. Seldin,Rodney H. Falk,Calum A. MacRae,Ronglih Liao +12 more
TL;DR: Impaired lysosomal function is identified to be the major cause of defective autophagy and amyloidogenic LC-induced proteotoxicity and potential targeting of autophagic and lysOSomal dysfunction in patients with amyloids cardiomyopathy is highlighted.
Modulation of mTOR signaling as a strategy for the treatment of Pompe disease
TL;DR: Reactivation of mTOR in the whole muscle of Pompe mice by TSC knockdown resulted in the reversal of atrophy and a striking removal of autophagic buildup, and it was found that the aberrant mTOR signaling can be reversed by arginine.
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High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy.
TL;DR: This finding provides evidence for the first time that the thickened vascular basement membrane contributes to the development of excess permeability seen in diabetic retinopathy.
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