Kyle J. Minch
Seattle Biomed
11 Papers
27 Citations
Kyle J. Minch is an academic researcher from Seattle Biomed. The author has contributed to research in topics: GeneXpert MTB/RIF & Mycobacterium tuberculosis. The author has an hindex of 8, co-authored 10 publications.
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Papers
The Mycobacterium tuberculosis regulatory network and hypoxia.
James E. Galagan,Kyle J. Minch,Matthew W. Peterson,Anna Lyubetskaya,Elham Azizi,Linsday Sweet,Antonio L.C. Gomes,Tige R. Rustad,Gregory Dolganov,Irina Glotova,Thomas Abeel,Thomas Abeel,Chris Mahwinney,Adam D. Kennedy,Rene Allard,William Brabant,Andrew S Krueger,Suma Jaini,Brent Honda,Wen-Han Yu,Mark J. Hickey,Jeremy Zucker,Christopher D. Garay,Brian Weiner,Peter Sisk,Christian Stolte,Jessica K. Winkler,Yves Van de Peer,Paul Iazzetti,Diogo M. Camacho,Jonathan M. Dreyfuss,Yang Liu,Anca Dorhoi,Hans-Joachim Mollenkopf,Paul Drogaris,Julie Lamontagne,Yiyong Zhou,Julie Piquenot,Sang Tae Park,Sahadevan Raman,Stefan H. E. Kaufmann,Robert P. Mohney,Daniel Chelsky,D. Branch Moody,David R. Sherman,David R. Sherman,Gary K. Schoolnik +46 more
TL;DR: The first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq are taken and system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration is combined.
Hypoxia: a window into Mycobacterium tuberculosis latency.
TL;DR: The historical precedents linking hypoxia and latency, the gathering knowledge of M. tuberculosis hypoxic responses, and the role of these responses in tuberculosis latency are discussed, and promising avenues for future studies are identified.
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The DNA-binding network of Mycobacterium tuberculosis.
Kyle J. Minch,Tige R. Rustad,Eliza J. R. Peterson,Jessica K. Winkler,David J Reiss,Shuyi Ma,Mark J. Hickey,William Brabant,Bob Morrison,Serdar Turkarslan,Chris Mawhinney,James E. Galagan,Nathan D. Price,Nitin S. Baliga,David R. Sherman +14 more
TL;DR: In this article, the DNA binding and transcriptional profile of 80% of all predicted M. tuberculosis transcription factors were reported, and wide-spread dormant DNA binding was found across all predicted transcription factors.
A high-resolution network model for global gene regulation in Mycobacterium tuberculosis
Eliza J. R. Peterson,David J Reiss,Serdar Turkarslan,Kyle J. Minch,Tige R. Rustad,Christopher L. Plaisier,William J.R. Longabaugh,David R. Sherman,Nitin S. Baliga +8 more
TL;DR: A rational, model-driven approach to unearth novel MTB biology that operates under some but not all phases of infection, including 23 genes that are essential to host-pathogen interactions.
A comprehensive map of genome-wide gene regulation in Mycobacterium tuberculosis.
Serdar Turkarslan,Eliza J. R. Peterson,Tige R. Rustad,Kyle J. Minch,David J Reiss,Robert Morrison,Shuyi Ma,Nathan D. Price,David R. Sherman,Nitin S. Baliga +9 more
TL;DR: This study constructed the first systems-scale map of transcription factor binding sites and their regulatory target proteins in MTB, and describes the use of TF overexpression datasets to validate a global gene regulatory network model of MTB and describes an online source to explore the datasets.