Kye-Young Kim
National Institutes of Health
8 Papers
12 Citations
Kye-Young Kim is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Heavy meromyosin. The author has an hindex of 7, co-authored 7 publications.
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Papers
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
Kye-Young Kim,Mark V. Stevens,M. Hasina Akter,Sarah E. Rusk,Robert J. Huang,Alexandra O. Cohen,Audrey Noguchi,Danielle A. Springer,Alexander V. Bocharov,Tomas L. Eggerman,Der-Fen Suen,Richard J. Youle,Marcelo Amar,Alan T. Remaley,Michael N. Sack +14 more
TL;DR: Results demonstrate that Parkin is regulated in a lipid-dependent manner and modulates systemic fat uptake via ubiquitin ligase-dependent effects and contributes to premature Parkinsonism.
Platelet Mitochondrial Dysfunction is Evident in Type 2 Diabetes in Association with Modifications of Mitochondrial Anti-Oxidant Stress Proteins
TL;DR: The data suggest that the bone marrow compartment in type 2 diabetic subjects is exposed to increased mitochondrial oxidative stress with upregulation of nuclear-encoded antioxidant mitochondrial enzymes, which suggests that platelets, as "accessible human tissue", may be useful to measure the mitochondrial modulatory effects of emerging anti-diabetic therapeutics.
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An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
Siddhartha S. Jana,Siddhartha S. Jana,Kye-Young Kim,Jian Mao,Sachiyo Kawamoto,James R. Sellers,Robert S. Adelstein +6 more
TL;DR: Unlike most vertebrate non-muscle and smooth muscle myosin IIs, baculovirus-expressed mouse heavy meromyosin (HMM) II-C2 demonstrates no requirement for regulatory myOSin light chain (MLC20) phosphorylation for maximum actin-activated MgATPase activity or maximum in vitro motility as measured by the sliding actin filament assay.
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The B2 Alternatively Spliced Isoform of Nonmuscle Myosin II-B Lacks Actin-Activated MgATPase Activity and in Vitro Motility
TL;DR: The actin-activated MgATPase activity of a chimeric HMM with the 21-amino acid II-B2 sequence inserted into the homologous location in the heavy chain of HMM II-C is increased following MLC-20 phosphorylation, which indicates that the effect of the II- B2 insert is myosin heavy chain specific.
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Parkin in the regulation of fat uptake and mitochondrial biology emerging links in the pathophysiology of Parkinson’s Disease
Kye-Young Kim,Michael N. Sack +1 more
TL;DR: The identification that Parkin has a multifunctional role in modulating cellular fatty acid uptake and mitochondrial biology further strengthens the pathophysiologic link between fat metabolism, mitochondria and Parkinson's disease.
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