Kuo Du
10 Papers
Kuo Du is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 5 publications.
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Papers
Hedgehog Signaling: Implications in Liver Pathophysiology.
Rajesh Kumar Dutta,JiHye Jun,Kuo Du,A. M. Diehl +3 more
- 06 Oct 2023
TL;DR: It is concluded that Hedgehog signaling must be precisely controlled in adult liver cells in order to maintain liver health and that targeted disruption of the pathway in hepatocytes dysregulates lipid, cholesterol, and bile acid metabolism and promotes hepatic lipotoxicity, insulin resistance and senescence.
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Targeting senescent hepatocytes for treatment of metabolic dysfunction-associated steatotic liver disease and multi-organ dysfunction
Kuo Du,David S Umbaugh,Liuyang Wang,JiHye Jun,Rajesh K Dutta,Seh Hoon Oh,Niansheng Ren,Qiaojuan Zhang,Dennis C. Ko,Ana Ferreira,Jon Hill,Guannan Gao,Steven Pullen,Vaibhav Jain,S. Gregory,Manal F. Abdelmalek,Anna Mae Diehl +16 more
TL;DR: Researchers define a senescent hepatocyte gene signature (SHGS) linked to metabolic dysfunction-associated steatotic liver disease (MASLD) progression, and identify senolytics that selectively eliminate SHGS+ hepatocytes, improving MASLD and systemic health in mouse models.
2
WSTF nuclear autophagy regulates chronic but not acute inflammation.
Yu Wang,Vinay V Eapen,Yaosi Liang,Athanasios Kournoutis,Marc S. Sherman,Yanxin Xu,Angelique Onorati,Xianting Li,Xiaoting Zhou,Kathleen E. Corey,Kuo Du,Ana Maria Cabral Burkard,Chia-Kang Ho,Jing Xie,Hui Zhang,Raquel Maeso-Díaz,Xinyi Ma,Ulrike Rieprecht,Tara C. O’Brien,Murat Cetinbas,Lu Wang,Jihe Liu,Corey Bretz,Aaron P Havas,Zhuo Zhou,Shannan J. Ho Sui,Srinivas Vinod Saladi,Ruslan Sadreyev,P. Adams,Robert E. Kingston,Anna Mae Diehl,Benjamin A. Alman,Wolfram Goessling,Zhenyu Yue,Xiao-Fan Wang,Terje Johansen,Zhixun Dou +36 more
1
Plasticity, heterogeneity, and multifunctionality of hepatic stellate cells in liver pathophysiology
Kuo Du,JiHye Jun,Rajesh K Dutta,A. M. Diehl +3 more
TL;DR: How the inherent plasticity of HSCs is central to their dynamic roles both in maintaining liver homeostasis and orchestrating responses to liver injury is focused on.