Kun Yu

TL;DR: Manual acupuncture could alleviate the inflammation and pain of infected joints and enhance the immune networks in the early stage to act on RA and promoted the immune-network to a normal level at the late stage, and monocyte/macrophage and endothelial cells were the key cells of innate immunity and body cells.

TL;DR: Based on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems, this article put forward the scientific hypothesis that acupuncture regulates NEI network and key response media therein, so as to achieve anti-inflammatory and analgesic effects in target organs.

TL;DR: Findings provide novel evidence that the anti-inflammatory and analgesic effects of MA on RA act through phenotypic modulation involving the inhibition of M1 macrophage polarization and an increase in the Treg cell population, highlighting the potential therapeutic advantages of acupuncture in controlling pain and ameliorating inflammatory conditions.

TL;DR: The combination anti-PD-1 with DHA is an effective strategy for liver tumor treatment and YAP1 inhibition is a potential target for increasing A. muciniphila abundance to promote anti-PD-1 efficacy in liver tumors.