11 Papers
52 Citations
Kun Qu is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: MDA5 & Cooperativity. The author has an hindex of 6, co-authored 11 publications. Previous affiliations of Kun Qu include Molecular Medicine Partnership Unit.
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Papers
Structures and distributions of SARS-CoV-2 spike proteins on intact virions.
Zunlong Ke,Joaquín Otón,Kun Qu,Mirko Cortese,Vojtech Zila,Lesley McKeane,Takanori Nakane,Jasenko Zivanov,Christopher J. Neufeldt,Berati Cerikan,John M. Lu,Julia Peukes,Xiaoli Xiong,Hans-Georg Kräusslich,Sjors H.W. Scheres,Ralf Bartenschlager,Ralf Bartenschlager,John A. G. Briggs +17 more
TL;DR: Cryo-electron microscopy and tomography is applied to image intact SARS-CoV-2 virions, determining the high-resolution structure, conformational flexibility and distribution of S trimers in situ on the virion surface and providing a basis from which to understand interactions between S and neutralizing antibodies during infection or vaccination.
A thermostable, closed SARS-CoV-2 spike protein trimer.
Xiaoli Xiong,Kun Qu,Katarzyna A. Ciazynska,Myra Hosmillo,Andrew P. Carter,Soraya Ebrahimi,Zunlong Ke,Sjors H.W. Scheres,Laura Bergamaschi,Guinevere L. Grice,Ying Zhang,Ying Zhang,James A. Nathan,Stephen Baker,Leo C. James,Helen Baxendale,Ian Goodfellow,Rainer Doffinger,John A. G. Briggs +18 more
TL;DR: It is demonstrated that the designed, thermostable, closed S trimer can be used in serological assays and has potential applications as a reagent for serology, virology and as an immunogen.
Maturation of the matrix and viral membrane of HIV-1.
Kun Qu,Kun Qu,Zunlong Ke,Zunlong Ke,Vojtech Zila,Vojtech Zila,Maria Anders-Össwein,Bärbel Glass,Frauke Mücksch,Rainer Müller,Carsten Schultz,Carsten Schultz,Barbara Dr. Müller,Barbara Dr. Müller,Hans-Georg Kräusslich,John A. G. Briggs +15 more
TL;DR: In this paper, the structure and arrangement of matrix (MA) within immature and mature HIV-1 through cryo-electron tomography was determined. And they found that MA rearranges between two different hexameric lattices upon maturation.
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The native structure of the assembled matrix protein 1 of influenza A virus.
Julia Peukes,Julia Peukes,Xiaoli Xiong,Xiaoli Xiong,Simon Erlendsson,Kun Qu,William Wan,Leslie J. Calder,Oliver Schraidt,Susann Kummer,Susann Kummer,Stefan M.V. Freund,Hans-Georg Kräusslich,John A. G. Briggs +13 more
TL;DR: Structures of the assembled matrix protein 1 of influenza A virus in intact virus particles and of oligomers of this protein reconstituted in vitro reveal mechanisms of assembly and disassembly of influenza virus.
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Structures, conformations and distributions of SARS-CoV-2 spike protein trimers on intact virions
Zunlong Ke,Joaquín Otón,Kun Qu,Mirko Cortese,Vojtech Zila,Lesley McKeane,Takanori Nakane,Jasenko Zivanov,Christopher J. Neufeldt,John M. Lu,Julia Peukes,Xiaoli Xiong,Hans-Georg Kräusslich,Sjors H.W. Scheres,Ralf Bartenschlager,John A. G. Briggs +15 more
TL;DR: Cryo-electron microscopy and tomography is applied to image intact SARS-CoV-2 virions, determining the high-resolution structure, conformational flexibility and distributions of S trimers in situ on the virion surface to provide a basis for understanding the conformations of S present on thevirion, and for studying their interactions with neutralizing antibodies.