Kun-peng Yang
Harbin Medical University
5 Papers
1 Citations
Kun-peng Yang is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction
Min Fan,Kun-peng Yang,Xiaohui Wang,Linjian Chen,P. Spencer Gill,Tuanzhu Ha,Li Lu,Nicole Lewis,David R. Williams,Chuanfu Li +9 more
TL;DR: In this article , a previously unknown function that increases cardiac fibrosis and exacerbates cardiac dysfunction by promoting EndoMT following myocardial infarction (MI) was reported.
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Lactate induces vascular permeability via disruption of VE-cadherin in endothelial cells during sepsis
Kun-peng Yang,Min Fan,Xiaohui Wang,Jingjing Xu,Yana Wang,P. Spencer Gill,Tuanzhu Ha,Li Lu,Jennifer V Hall,David R. Williams,Chuanfu Li +10 more
TL;DR: It is shown that lactate causes vascular permeability and worsens organ dysfunction in CLP sepsis and metabolic cross-talk between glycolysis-derived lactate and the endothelium plays a critical role in the pathophysiology of sepsi.
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Role of Kit4.1 and aquaporin--4 in focal brain ischemia-reperfusion injury in rats
TL;DR: Kir4.1 and AQP4 react with each other in the course of focal brain ischemia-reperfusion, both playing roles in the mechanism of brain IR injury.
1
Abstract 14872: Lactate Promotes Endothelial-to-Mesenchymal Transition via Snail1 Lactylation After Myocardial Infarction
TL;DR: In this paper , the authors investigated whether lactate exerts a biological role in EndMT following myocardial infarction (MI), and they concluded that lactate acts as an important molecule that upregulates cardiac fibrosis after MI via induction of Snail1 and nuclear translocation to activate TGF-β/Smad2 pathway.
Lactate impairs vascular permeability by inhibiting hspa12b expression via gpr81-dependent signaling in sepsis
Min Fan,Kun-peng Yang,Xiaohui Wang,Xiang Zhang,Jingjing Xu,Fei Tu,P. Spencer Gill,Tuanzhu Ha,David R. Williams,Chuanfu Li +9 more
TL;DR: A novel role of lactate is demonstrated in promoting vascular permeability by decreasing VE-cadherin junctions and tight junctions in endothelial cells and reversing HSPA12B expression in septic mice.