5 Papers
Kun Peng is an academic researcher from University of Electronic Science and Technology of China. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Disruption of Tmem30a results in cerebellar ataxia and degeneration of Purkinje cells
Yeming Yang,Kuanxiang Sun,Wenjing Liu,Lin Zhang,Kun Peng,Shanshan Zhang,Shujin Li,Mu Yang,Zhilin Jiang,Zhilin Jiang,Fang Lu,Xianjun Zhu +11 more
TL;DR: It is demonstrated that loss of Tmem30a in PCs results in protein folding and transport defects, a substantial decrease in dendritic spine density, increased astrogliosis and PC death, and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis suggested that apoptotic cell death occurred in the cerebellum.
Gut-licensed β7+ CD4+ T cells contribute to progressive retinal ganglion cell damage in glaucoma
Chong He,Wenbo Xiu,Qinyuan Chen,Kun Peng,Xiong Zhu,Zuo Wang,Xiang-shu Xu,Yangkang Chen,Gao-Yuan Zhang,Jing Fu,Qiwei Dong,Xiaoqiong Wu,An Li,Donghua Liu,Yanping Gao,Jin-Xia Wang,Zhao Wang,Bolin Deng,Ping Shuai,Caiping Gao,Yilian Chen,Ling Yu,Fang Lu +22 more
TL;DR: A role of gut-licensed β7+ CD4+ T cells and MAdCAM-1 in RGC degeneration is revealed and the importance of the “gut-retina” axis in glaucoma is emphasized.
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TMEM30A is essential for hair cell polarity maintenance in postnatal mouse cochlea
TL;DR: In this article , the authors investigated hair cell and stereocilia morphological changes by immunofluorescence staining and quantitative real-time polymerase chain reaction (qRT-PCR) at different developmental stages.
Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner
Chong He,Kun Peng,Xiong Zhu,Zuo Wang,Wenbo Xiu,Gao Zhang,Yang Chen,Chaonan Sun,Xiao Xiao,Donghua Liu,An Li,Yanping Gao,Jin-Xia Wang,Ping Shuai,Yilian Chen,Ling Yu,Fang Lu +16 more
TL;DR: Novel insights are provided into the role of peripheral CD4^+ T cells in glaucoma pathogenesis, shedding light on the mechanisms underlying their infiltration into the retina and offering potential avenues for innovative therapeutic interventions in this sight-threatening disease.
Carnosol Maintains Intestinal Barrier Function and Mucosal Immune Homeostasis in DSS-Induced Colitis
Xiang Xu,Gao Zhang,Kun Peng,Yanping Gao,Jinxia Wang,C. Gao,Chong He,Fang Lu +7 more
TL;DR: It is found that CA significantly alleviated DSS-induced colitis in mice marked by relieved clinical symptoms and colonic pathological damage and maintains proper epithelial barrier functions via suppressing epithelial ER stress, providing new evidence that CA might be a promising therapeutic candidate for UC.