Kun Lu
Emory University
10 Papers
113 Citations
Kun Lu is an academic researcher from Emory University. The author has contributed to research in topics: Chemistry & Fibril. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Kun Lu include Argonne National Laboratory.
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Papers
Exploiting amyloid fibril lamination for nanotube self-assembly.
TL;DR: Homogeneous arrays of solvent-filled nanotubes arising from a flat rectangular bilayer, 130 nm wide x 4 nm thick, with each bilayer leaflet composed of laminated beta-sheets offer a unique, robust, and easily accessible scaffold for nanotechnology.
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Facial symmetry in protein self-assembly.
Anil K. Mehta,Kun Lu,W. Seth Childers,Yan Liang,Steven N. Dublin,Jijun Dong,James P. Snyder,Sai Venkatesh Pingali,Pappannan Thiyagarajan,David G. Lynn +9 more
TL;DR: Spectroscopic and microscopy analyses are combined to reveal the subtle atomic-level differences that dictate assembly of two conformationally pure Abeta(16-22) assemblies, amyloid fibers and nanotubes, and define the minimal repeating unit for each assembly.
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Templating Molecular Arrays in Amyloid’s Cross-β Grooves
TL;DR: The structure of cross-beta nanotubes, which limit the number of potential binding sites, are exploited to directly interrogate cross- beta laminate grooves and illuminate the ability of the amyloid to organize molecules into extended arrays that underlie the remarkable diagnostic potential of CR.
73
Metal Switch for Amyloid Formation: Insight into the Structure of the Nucleus
David M. Morgan,Jijun Dong,Jaby Jacob,Kun Lu,Robert P. Apkarian,Pappannan Thiyagarajan,David G. Lynn +6 more
TL;DR: Fibril morphology, as determined by small angle neutron scattering (SANS) and transmission electron microscopy (TEM), was unchanged in the presence and absence of Zn2+ in Abeta(10-21), as well as in a series of site-specifically altered variants.
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Macroscale assembly of peptide nanotubes
Kun Lu,Liang Guo,Anil K. Mehta,W. Seth Childers,Steven N. Dublin,S. Skanthakumar,Vincent P. Conticello,Pappannan Thiyagarajan,Robert P. Apkarian,David G. Lynn +9 more
TL;DR: Simple oligopeptides that self-assemble into homogeneous nanotubes can be directed to further assemble into macroscale parallel arrays through protein "salting out" strategies.
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