18 Papers
3 Citations
Kun Ke is an academic researcher from Fujian Medical University. The author has contributed to research in topics: Metastasis & Medicine. The author has an hindex of 8, co-authored 17 publications.
Chat about Author
Papers
Personalized neoantigen-based immunotherapy for advanced collecting duct carcinoma: case report.
Yongyi Zeng,Wei Zhang,Zhenli Li,Youshi Zheng,Wang Yingchao,Geng Chen,Liman Qiu,Kun Ke,Su Xiaoping,Cai Zhixiong,Jingfeng Liu,Xiaolong Liu +11 more
TL;DR: The case report demonstrated that the combined therapy of neoantigen peptide vaccination and NRT cell infusion showed certain efficacy in this CDC case, even when the patient carried only a relatively low tumor mutation burden.
55
FGG promotes migration and invasion in hepatocellular carcinoma cells through activating epithelial to mesenchymal transition.
Xiang Zhang,Fei Wang,Yanbing Huang,Kun Ke,Bixing Zhao,Lihong Chen,Naishun Liao,Lei Wang,Qin Li,Xiaolong Liu,Yingchao Wang,Jingfeng Liu +11 more
TL;DR: Clinical pathological analysis demonstrated that upregulation of intracellular FGG was significantly associated with increased vascular invasion, more satellite nodules, and more advanced TNM stage, and HCC patients with stronger expression of FGG had a higher recurrence rate and correspondingly a shorter overall survival time.
An Optogenetic Controllable T Cell System for Hepatocellular Carcinoma Immunotherapy.
Bixing Zhao,Yingchao Wang,Xionghong Tan,Xiaoyuan Zheng,Fei Wang,Kun Ke,Cuilin Zhang,Naishun Liao,Yuan Dang,Yingjun Shi,Youshi Zheng,Yunzhen Gao,Qin Li,Xiaolong Liu,Jingfeng Liu +14 more
TL;DR: This optogenetic engineering strategy significantly enhanced the expansion ability and cytolytic activity of primary T cells upon light irradiation, and the light activated T cells showed high-efficiency of elimination against xenograft of hepatocellular carcinoma cells.
41
Inflammatory Micro-environment Contributes to Stemness Properties and Metastatic Potential of HCC via the NF-κB/miR-497/SALL4 Axis.
Bixing Zhao,Bixing Zhao,Yingchao Wang,Yingchao Wang,Xionghong Tan,Kun Ke,Xiaoyuan Zheng,Fei Wang,Shubing Lan,Naishun Liao,Naishun Liao,Zhixiong Cai,Zhixiong Cai,Yingjun Shi,Youshi Zheng,Youshi Zheng,Yongping Lai,Lili Wang,Qin Li,Qin Li,Jingfeng Liu,Jingfeng Liu,Aimin Huang,Xiaolong Liu,Xiaolong Liu +24 more
TL;DR: The findings revealed a novel signaling pathway (NF-κB/miR-497/SALL4 axis) to connect inflammation with stemness properties, and clarified the molecular mechanisms underlying the inflammation-mediated self-renewal and metastasis phenotypes, but also provided novel molecular targets for developing new anticancer strategies.
36
Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.
Ming Li,Xiaomo Wu,Ju Gao,Fen Yang,Cui-Lin Zhang,Kun Ke,Yingchao Wang,Youshi Zheng,Jianfeng Yao,Yingying Guan,Xuan Chen,Juan Chen,Xiaolong Liu,Xiaoyu Yang +13 more
TL;DR: Four novel mutations are identified within the P10 subunit of procaspase-8 that are highly correlated with chemotherapy resistance and poor prognosis of acute myeloid leukemia (AML) patients, and could be used as novel biomarkers for predicting response and survival of chemotherapy-treated AML patients and potential therapeutic targets for medical intervention in the future.