10 Papers
Kun He is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Immune system & Chemistry. The author has an hindex of 7, co-authored 9 publications.
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Papers
The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4 + T-cell-mediated antitumor memory immune response
Kun He,Ping Liu,Lisa X. Xu +2 more
TL;DR: It was found that good therapeutic effect was mainly dependent on CD4+ T cells providing a durable memory antitumor immune response, and significant increase of serum IFN-γ was also observed to provide an ideal microenvironment of antitumors immunity.
•Journal Article
Tumor associated macrophages deliver iron to tumor cells via Lcn2.
TL;DR: It is found that iron concentration was significantly increased at tumor metastatic stage, which could be attributed to up-regulated expression of lipocalin2 (Lcn2), and TAMs in the microenvironment secreted Lcn2 which acted as an iron transporter.
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Deferoxamine-induced increase in the intracellular iron levels in highly aggressive breast cancer cells leads to increased cell migration by enhancing TNF-α-dependent NF-κB signaling and TGF-β signaling.
TL;DR: This study modulated the intracellular iron levels of human breast cancer cells, including the aggressive MDA-MB-231 cells and non-aggressive MCF-7 cells, by using Deferoxamine (DFO) - a most widely used iron chelator, and provided the first evidence suggesting that increased intrace cellular iron levels could lead to enhanced migration of aggressive breast cancers by increasing TNF-α-dependent NF-κB signaling and TGF-β signaling.
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Cryo-thermal therapy elicits potent anti-tumor immunity by inducing extracellular Hsp70-dependent MDSC differentiation.
TL;DR: It is found that local cryo-thermal therapy resulted in a considerable reduction of distant lung metastases, and improved long-term survival, and results of tumor re-challenge experiments indicated generation of a strong tumor-specific immune memory after the local treatment of primary tumors.
PD-L1 expression on circulating tumor cells can be a predictive biomarker to PD-1 inhibitors combined with radiotherapy and antiangiogenic therapy in advanced hepatocellular carcinoma
Ke Su,Lu Guo,Kun He,Mingyue Rao,Jianwen Zhang,Xiaoli Yang,Wei Huang,Tao Gu,Ke Xu,Yanlin Liu,Jing Wang,Jiali Chen,Zhen-Feng Wu,L-J Hu,Hao Zeng,Hongyan Li,Jian Tong,Xueting Li,Yue Yang,Hanlin Liu,Yao Xu,Zunyuan Tan,Xueyan Tang,Xunjie Feng,Siyu Chen,Binbin Yang,Hongping Jin,Lechuan Zhu,Bo Li,Junwei Han +29 more
TL;DR: It is demonstrated that PD-L1+ CTCs could be a predictive biomarker for HCC patients receiving PD-1 inhibitors in combination with intensity-modulated radiotherapy (IMRT) and antiangiogenic therapy.