Kun Gou
Sichuan University
11 Papers
Kun Gou is an academic researcher from Sichuan University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 1, co-authored 2 publications.
Chat about Author
Papers
DHODH and cancer: promising prospects to be explored
Yue Zhou,Lei Tao,Xia Zhou,Zeping Zuo,Jin Gong,Xiaocong Liu,Yang Zhou,Chunqi Liu,Na Sang,Huan Liu,Jiao Zou,Kun Gou,Xiaowei Yang,Yinglan Zhao +13 more
TL;DR: In this paper, the authors mainly unravel the biological function of DHODH in tumor progression, including its crucial role in de novo pyrimidine synthesis and mitochondrial respiratory chain in cancer cells.
Epigenetic regulation in cancer therapy: From mechanisms to clinical advances
Lei Tao,Yuee Zhou,Yuan Luo,Jia-Hui Qiu,Yuzhou Xiao,Jiao Zou,Yu Zhang,Xingchen Liu,Xinyu Yang,Kun Gou,Jing Xu,Xinqi Guan,Xiaobo Cen,Yinglan Zhao +13 more
- 04 Jan 2024
TL;DR: The essential regulatory mechanisms and dysfunctions of epigenetic regulators involved in DNA methylation, histone methylation, and histone acetylation during tumor development and progression are summarized.
17
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
Lei Tao,Yuee Zhou,Xiangyu Pan,Yuan Luo,Jia-Hui Qiu,Xia Zhou,Zhiqian Chen,Yan Li,Lian Xu,Yangli Zhou,Zeping Zuo,Chunqi Liu,Liang Wang,Xiaocong Liu,Xinyu Tian,Na Su,Yu Zhang,Kun Gou,Na Sang,Huan Liu,Jiao Zou,Yuzhou Xiao,Xincheng Zhong,Jing Xu,Xinyu Yang,Kai Xiao,Yanyang Liu,Sheng-Hsiung Yang,Yong Peng,Junhong Han,Xiaobo Cen,Yinglan Zhao +31 more
TL;DR: It is demonstrated that lysine-specific demethylase 1 (LSD1) is an important regulator for OC and combination with LSD1 inhibitor could greatly expand the utility of PARPi to patients with HR-proficient tumor, warranting assessment in human clinical trials.
8
Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold.
Chungen Li,Yuee Zhou,Jing Xu,Xia Zhou,Song Liu,Zong-Zhi Huang,Zhiqiang Qiu,Ting Zeng,Kun Gou,Lei Tao,Xincheng Zhong,Xiaowei Yang,Yangli Zhou,Na Su,Qiang Chen,Yinglan Zhao,Youfu Luo +16 more
TL;DR: In this article , the authors designed and synthesized seven different teriflunomide derivatives and four ASLAN003 derivatives based on a benzophenone scaffold to suppress the proliferation of cancer cells and activated lymphocytes.
6
Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy.
Xia Zhou,Yuping Tan,Kun Gou,Lei Tao,Yuan Luo,Yue Zhou,Zeping Zuo,Qingxiang Sun,Youfu Luo,Yinglan Zhao +9 more
TL;DR: In this article, the authors identified H-G6 as a potential PHGDH inhibitor from the screening of an in-house small molecule library based on the enzymatic assay.
5