Ksenia Pumpor
University of Lübeck
4 Papers
14 Citations
Ksenia Pumpor is an academic researcher from University of Lübeck. The author has contributed to research in topics: Coronavirus & Avian infectious bronchitis virus. The author has an hindex of 4, co-authored 4 publications.
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Papers
The SARS-coronavirus-host interactome
Susanne Pfefferle,Julia Schöpf,Manfred Kögl,Caroline C. Friedel,Marcel A. Müller,Javier Carbajo-Lozoya,Thorsten Stellberger,Ekatarina von Dall'Armi,Petra Herzog,Stefan Kallies,Daniela Niemeyer,Vanessa Ditt,Thomas Kuri,Roland Züst,Ksenia Pumpor,Rolf Hilgenfeld,Frank Schwarz,Ralf Zimmer,Imke Steffen,Friedemann Weber,Volker Thiel,Georg Herrler,Heinz-Jürgen Thiel,Christel Schwegmann-Wessels,Stefan Pöhlmann,Juergen Haas,Christian Drosten,Albrecht von Brunn +27 more
TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.
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Sometimes Intermediates Do the Job
Rolf Hilgenfeld,Ksenia Pumpor +1 more
TL;DR: Wu et al. as discussed by the authors describe potent inhibition of the SARS coronavirus main proteinase by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives.
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A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters.
Koen H.G. Verschueren,Ksenia Pumpor,Stefan Anemüller,Shuai Chen,Jeroen R. Mesters,Rolf Hilgenfeld +5 more
TL;DR: In this article, the main proteinase (M(pro)) of the severe acute respiratory syndrome (SARS) coronavirus is a principal target for the design of anticoronaviral compounds.
The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
Susanne Pfefferle,Julia Schöpf,Manfred Kögl,Caroline C. Friedel,Caroline C. Friedel,Marcel A. Müller,Javier Carbajo-Lozoya,Thorsten Stellberger,Ekatarina von Dall'Armi,Petra Herzog,Stefan Kallies,Daniela Niemeyer,Vanessa Ditt,Thomas Kuri,Roland Züst,Ksenia Pumpor,Rolf Hilgenfeld,Frank Schwarz,Ralf Zimmer,Imke Steffen,Friedemann Weber,Friedemann Weber,Volker Thiel,Georg Herrler,Heinz Jürgen Thiel,Christel Schwegmann-Weßels,Stefan Pöhlmann,Jürgen Haas,Jürgen Haas,Christian Drosten,Albrecht von Brunn +30 more
TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.