Kriti Agrawal
University of California, San Diego
7 Papers
Kriti Agrawal is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Immunotherapy & Immune system. The author has an hindex of 6, co-authored 6 publications.
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Papers
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
Na Li,Yuqi Kang,Lingling Wang,Sarah Huff,Rachel Tang,Hui Hui,Kriti Agrawal,Gwendolyn Gonzalez,Yinsheng Wang,Sandip Pravin Patel,Tariq M. Rana +10 more
TL;DR: It is shown that deletion of the m6A demethylase Alkbh5 sensitized tumors to cancer immunotherapy and identified ALKBH5 as a potential therapeutic target to enhance immunotherapy outcome in melanoma, colorectal, and potentially other cancers.
m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
TL;DR: These findings uncover a new awareness of the function of RNA methylation in adaptive immunity and provide METTL3 and METTL14 as potential therapeutic targets in anticancer immunotherapy.
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Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids.
TL;DR: The data suggest that human cerebral organoids represent a model system to study drug-induced neuroinflammation at single-cell resolution and upregulation of immediate early genes, complement factors, apoptosis, and immune response genes suggests a neuroinflammatory program induced by METH regulating neural stem cell proliferation, differentiation, and cell death.
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Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity.
Min Tang,Shashi Kant Tiwari,Kriti Agrawal,Matthew Tan,Jason Dang,Trevor Tam,Jing Tian,Xueyi Wan,Jacob Schimelman,Shangting You,Qinghui Xia,Tariq M. Rana,Shaochen Chen +12 more
TL;DR: In this article, a biomimetic tri-regional GBM model with tumor regions, acellular ECM regions, and an endothelial region with regional stiffnesses patterned corresponding to the GBM stroma, pathological or normal brain parenchyma, and brain capillaries is developed.
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An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics.
TL;DR: Analysis of single-cell RNA sequencing of peripheral blood mononuclear cells provides a comprehensive analysis of gene signatures associated with immune cell exhaustion during HIV infection, which could be useful in understanding exhaustion mechanisms and developing new cure therapies.
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