Kristen E. Pascal
Regeneron
22 Papers
47 Citations
Kristen E. Pascal is an academic researcher from Regeneron. The author has contributed to research in topics: Antibody & Biology. The author has an hindex of 15, co-authored 19 publications.
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Papers
Concurrent human antibody andTH1 type T-cell responses elicited by a COVID-19 RNA vaccine
Ugur Sahin,Alexander Muik,Evelyna Derhovanessian,Isabel Vogler,Lena M. Kranz,Mathias Vormehr,Alina Baum,Kristen E. Pascal,Jasmin Quandt,Daniel Maurus,Sebastian Brachtendorf,Verena L Loerks,Julian Sikorski,Rolf Hilker,Dirk Becker,Ann-Kathrin Eller,Jan Gruetzner,Carsten Boesler,Corinna Rosenbaum,Marie-Cristine Kuehnle,Ulrich Luxemburger,Alexandra Kemmer-Brueck,David J. Langer,Martin Bexon,Stefanie Bolte,Katalin Karikó,Tania Palanche,Boris Fischer,Armin Schultz,Pei Yong Shi,Camila R. Fontes-Garfias,John L. Perez,Kena A. Swanson,Jakob Loschko,Ingrid L. Scully,Mark Cutler,Warren Kalina,Christos A. Kyratsous,David A. Cooper,Philip R. Dormitzer,Kathrin U. Jansen,Oezlem Tuereci +41 more
TL;DR: The robust RBD-specific antibody, T-cell and favourable cytokine responses induced by the BNT162b1 mRNA vaccine suggest multiple beneficial mechanisms with potential to protect against COVID-19.
Uropathogenic Escherichia coli dominantly suppress the innate immune response of bladder epithelial cells by a lipopolysaccharide- and Toll-like receptor 4-independent pathway
TL;DR: Uropathogenic E. coli suppress the innate immune response through a pathway partially independent of lipopolysaccharide and Toll-like receptor 4, and that suppression is not a consequence of toxicity.
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Rapid detection of Atopobium vaginae and association with organisms implicated in bacterial vaginosis.
Jason Trama,Kristen E. Pascal,Jessica A. Zimmerman,Matthew J. Self,Eli Mordechai,Martin E. Adelson +5 more
TL;DR: Sequencing of an A. vaginae genomic library has led to the development of a highly specific and sensitive real-time PCR test for detection of Atopobium vaginae directly from gynecological cervicovaginal swab samples, suggesting that further clinical study of the relationship of A. vaginale with G. vaginalis and theDevelopment of BV should be performed.
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Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and T H 1 T cell responses.
Ugur Sahin,Alexander Muik,Evelyna Derhovanessian,Isabel Vogler,Lena M. Kranz,Mathias Vormehr,Alina Baum,Kristen E. Pascal,Jasmin Quandt,Daniel Maurus,Sebastian Brachtendorf,Verena Lörks,Julian Sikorski,Rolf Hilker,Dirk Becker,Ann Kathrin Eller,Jan Grützner,Carsten Boesler,Corinna Rosenbaum,Marie Cristine Kühnle,Ulrich Luxemburger,Alexandra Kemmer-Brück,David J. Langer,Martin Bexon,Stefanie Bolte,Katalin Karikó,Tania Palanche,Boris Fischer,Armin Schultz,Pei Yong Shi,Camila R. Fontes-Garfias,John L. Perez,Kena A. Swanson,Jakob Loschko,Ingrid L. Scully,Mark Cutler,Warren Kalina,Christos A. Kyratsous,David A. Cooper,Philip R. Dormitzer,Kathrin U. Jansen,Özlem Türeci +41 more
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Structure of the Inmazeb cocktail and resistance to Ebola virus escape.
Vamseedhar Rayaprolu,Benjamin O. Fulton,Ashique Rafique,Emilia C. Arturo,Dewight Williams,C. Hariharan,Heather M. Callaway,Amar D. Parvate,Sharon L. Schendel,Diptiben V. Parekh,Sean Hui,Kelly J. Shaffer,Kristen E. Pascal,Elzbieta Wloga,Stephanie Giordano,Nicole Negron,Min Ni,Richard Copin,Gurinder S. Atwal,Matthew C. Franklin,RuthMabel Boytz,Callie J Donahue,Robert A. Davey,Alina Baum,Christos A. Kyratsous,Erica Ollmann Saphire +25 more
TL;DR: Inmazeb (REGN-EB3) as mentioned in this paper , a three-antibody cocktail against Ebola virus, lessened disease and improved survival in a controlled trial.
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