Kristen E. Pascal
Regeneron
22 Papers
47 Citations
Kristen E. Pascal is an academic researcher from Regeneron. The author has contributed to research in topics: Antibody & Biology. The author has an hindex of 15, co-authored 19 publications.
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Papers
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +24 more
TL;DR: D614G adopts conformations that make virion membrane fusion with the target cell membrane more probable but that D614G retains susceptibility to therapies that disrupt interaction of the SARS-CoV-2 S protein with the ACE2 receptor.
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Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection
Kristen E. Pascal,Christopher M. Coleman,Alejandro O. Mujica,Vishal Kamat,Ashok Badithe,Jeanette L. Fairhurst,Charleen Hunt,John Strein,Alexander Berrebi,Jeanne M. Sisk,Krystal Matthews,Robert Babb,Gang Chen,Ka Man V. Lai,Tammy T. Huang,William C. Olson,George D. Yancopoulos,Neil Stahl,Matthew B. Frieman,Christos A. Kyratsous +19 more
TL;DR: The rapid generation of fully human neutralizing antibodies against the recently emerged Middle East Respiratory Syndrome coronavirus (MERS-CoV) are shown and development of a humanized mouse model for MERS- coV infection was used to demonstrate the therapeutic efficacy of the isolated antibodies.
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The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies.
Richard Copin,Alina Baum,Elzbieta Wloga,Kristen E. Pascal,Stephanie Giordano,Benjamin O. Fulton,Anbo Zhou,Nicole Negron,Kathryn Lanza,Newton Chan,Angel Coppola,Joyce Chiu,Min Ni,Yi Wei,Gurinder S. Atwal,Annabel Romero Hernandez,Kei Saotome,Yi Zhou,Matthew C. Franklin,Andrea T. Hooper,Shane McCarthy,Sara Hamon,Jennifer D. Hamilton,Hilary M. Staples,Kendra J. Alfson,Ricardo Carrion,Shazia Ali,Thomas Norton,Selin Somersan-Karakaya,Sumathi Sivapalasingam,Gary Herman,David M. Weinreich,Leah Lipsich,Neil Stahl,Andrew J. Murphy,George D. Yancopoulos,Christos A. Kyratsous +36 more
TL;DR: In this paper, the sequence diversity of the spike protein and monitored emergence of virus variants in SARS-CoV-2 isolates found in COVID-19 patients treated with the two-antibody combination REGEN-COV, as well as in preclinical in vitro studies using single, dual, or triple antibody combinations.
203
Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates.
Kristen E. Pascal,Drew Dudgeon,John C. Trefry,Manu Anantpadma,Yasuteru Sakurai,Charles D. Murin,Hannah L. Turner,Jeanette L. Fairhurst,Marcela Torres,Ashique Rafique,Ying Yan,Ashok Badithe,Kevin Yu,Terra Potocky,Sandra L. Bixler,Taylor B. Chance,William D. Pratt,Franco Rossi,Joshua D. Shamblin,Suzanne E. Wollen,Justine M. Zelko,Ricardo Carrion,Gabriella Worwa,Hilary M. Staples,Darya Burakov,Robert Babb,Gang Chen,Joel H. Martin,Tammy T. Huang,Karl J. Erlandson,Melissa S Willis,Kimberly Armstrong,Thomas M Dreier,Andrew B. Ward,Robert A. Davey,Margaret L. Pitt,Leah Lipsich,Peter W. Mason,William C. Olson,Neil Stahl,Christos A. Kyratsous +40 more
TL;DR: A single dose of a cocktail of the 3 antibodies protected nonhuman primates (NHPs) from EBOV disease even after disease symptoms were apparent, and demonstrates high-level postexposure protection from lethal E BOV disease in NHPs.
Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis
TL;DR: The results suggest that Atopobium vaginae stimulates an innate immune response from vaginal epithelial cells, leading to localized cytokine and defensin production, and possibly contributes to the pathogenesis of bacterial vaginosis.
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