Krista D. Stackley
Medical University of South Carolina
8 Papers
32 Citations
Krista D. Stackley is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Biology & Mitochondrial DNA. The author has an hindex of 8, co-authored 8 publications.
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Papers
Bioenergetic profiling of zebrafish embryonic development.
TL;DR: It is demonstrated that changes in the coupling to ATP turnover and proton leak are correlated with developmental stage and the multiwell format of this assay enables the user to screen for the effects of drugs and environmental agents on bioenergetics in the zebrafish embryo with high sensitivity and reproducibility.
The Effects of Three Chemical Algaecides on Cell Numbers and Toxin Content of the Cyanobacteria Microcystis aeruginosa and Anabaenopsis sp.
Dianne I. Greenfield,Dianne I. Greenfield,Ashley Duquette,Abby Goodson,Charles J. Keppler,Sarah H. Williams,Larissa M. Brock,Krista D. Stackley,David White,Susan B. Wilde +9 more
TL;DR: Findings indicate that algaecide applications may visibly control cyanobacteria bloom densities, but not necessarily toxin concentrations, and have implications for public health and safety.
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Opa1 is required for proper mitochondrial metabolism in early development.
TL;DR: Opa1 was successfully depleted in zebrafish embryos using antisense morpholinos, which resulted in disrupted mitochondrial morphology and a new Opa1-associated phenotype in a vertebrate model system, which further elucidates the absolute requirement of OPA1 for successful vertebrate development.
Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability.
Iryna Bohovych,Mario R. Fernandez,Jennifer J. Rahn,Krista D. Stackley,Jennifer E. Bestman,Annadurai Anandhan,Rodrigo Franco,Steven M. Claypool,Robert E. Lewis,Sherine S.L. Chan,Oleh Khalimonchuk +10 more
TL;DR: In this paper, the IMQC protease Oma1 is shown to be essential for the stability of the respiratory supercomplexes and thus balanced and tunable bioenergetic function.
The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos.
TL;DR: DNP-treated embryos were incapable of sustaining this mitochondrial biogenic response past mid-embryogenesis, as shown by significantly lowered ATP production and ATP levels, decreased gene expression, and the onset of developmental defects.
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