Krishna P. Bhat
University of Texas MD Anderson Cancer Center
54 Papers
58 Citations
Krishna P. Bhat is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 22, co-authored 42 publications. Previous affiliations of Krishna P. Bhat include Johns Hopkins University School of Medicine & University of Texas Health Science Center at Houston.
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Papers
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.
Houtan Noushmehr,Daniel J. Weisenberger,Kristin Diefes,Heidi S. Phillips,Kanan Pujara,Benjamin P. Berman,Fei Pan,Christopher E. Pelloski,Erik P. Sulman,Krishna P. Bhat,Roel G.W. Verhaak,Roel G.W. Verhaak,Katherine A. Hoadley,D. Neil Hayes,Charles M. Perou,Heather Schmidt,Li Ding,Richard K. Wilson,David Van Den Berg,Hui Shen,Henrik Bengtsson,Pierre Neuvial,Leslie Cope,Jonathan D. Buckley,James G. Herman,Stephen B. Baylin,Peter W. Laird,Kenneth Aldape +27 more
TL;DR: G-CIMP tumors belong to the proneural subgroup, are more prevalent among lower-grade gliomas, display distinct copy-number alterations, and are tightly associated with IDH1 somatic mutations.
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Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.
Koji Itahana,Krishna P. Bhat,Aiwen Jin,Yoko Itahana,David H. Hawke,Ryuji Kobayashi,Yanping Zhang +6 more
TL;DR: It is shown that ARF interacts with B23, a multifunctional nucleolar protein involved in ribosome biogenesis, and promotes its polyubiquitination and degradation, and suggests a nucleolar role of ARF in surveillance of oncogenic insults.
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Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.
Konrad Gabrusiewicz,Benjamin Rodriguez,Jun Wei,Yuuri Hashimoto,Luke M. Healy,Sourindra Maiti,Ginu Thomas,Shouhao Zhou,Qianghu Wang,Ahmed Elakkad,Brandon D. Liebelt,Nasser K. Yaghi,Ravesanker Ezhilarasan,Neal Huang,Jeffrey S. Weinberg,Sujit S. Prabhu,Ganesh Rao,Raymond Sawaya,Lauren A. Langford,Janet M. Bruner,Gregory N. Fuller,Amit Bar-Or,Wei Li,Rivka R. Colen,Michael A. Curran,Krishna P. Bhat,Jack P. Antel,Laurence J.N. Cooper,Erik P. Sulman,Amy B. Heimberger +29 more
TL;DR: G GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype, and contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.
Epidermal Growth Factor Receptor Variant III Status Defines Clinically Distinct Subtypes of Glioblastoma
Christopher E. Pelloski,Karla V. Ballman,Alfred F. Furth,Li Zhang,E. Lin,Erik P. Sulman,Krishna P. Bhat,J. Matthew McDonald,W. K. Alfred Yung,Howard Colman,Shiao Y. Woo,Amy B. Heimberger,Dima Suki,Michael D. Prados,Susan M. Chang,Fred G. Barker,Jan C. Buckner,C. David James,Kenneth Aldape +18 more
TL;DR: Established prognostic factors in GBM were not predictive of outcome in the EGFRvIII-positive subset, although this requires confirmation in independent data sets.
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The molecular landscape of glioma in patients with Neurofibromatosis 1.
Fulvio D'Angelo,Michele Ceccarelli,Tala,Luciano Garofano,Jing Zhang,Veronique Frattini,Francesca Pia Caruso,Genevieve Lewis,Kristin Alfaro,Luc Bauchet,Giulia Berzero,David Cachia,Mario Cangiano,Laurent Capelle,John de Groot,Francesco DiMeco,François Ducray,Walid Farah,Gaetano Finocchiaro,Stéphane Goutagny,Carlos Kamiya-Matsuoka,Cinzia Lavarino,Hugues Loiseau,Véronique Lorgis,Carlo Efisio Marras,Ian E. McCutcheon,Do-Hyun Nam,Do-Hyun Nam,Susanna Ronchi,Veronica Saletti,Romuald Seizeur,John M. Slopis,Mariona Suñol,F. Vandenbos,Pascale Varlet,Dominique Vidaud,Colin Watts,Viviane Tabar,David E. Reuss,David E. Reuss,Seung-Ki Kim,David Meyronet,Karima Mokhtari,Hector Salvador,Krishna P. Bhat,Marica Eoli,Marc Sanson,Anna Lasorella,Antonio Iavarone +48 more
TL;DR: It is found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade, which defined a distinct landscape that recapitulates a subset of sporadic tumors.
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