Kouichi Higuchi
Osaka University
10 Papers
75 Citations
Kouichi Higuchi is an academic researcher from Osaka University. The author has contributed to research in topics: Indole test & Indole alkaloid. The author has an hindex of 6, co-authored 10 publications.
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Papers
Novel neuronal nitric oxide synthase (nNOS) selective inhibitor, aplysinopsin-type indole alkaloid, from marine sponge Hyrtios erecta
Shunji Aoki,Ying Ye,Kouichi Higuchi,Akira Takashima,Yoshimi Tanaka,Isao Kitagawa,Motomasa Kobayashi +6 more
TL;DR: Two novel aplysinopsin-type indole alkaloids and new quinolone 7 were isolated from the marine sponge Hyrtios erecta and exhibited selective inhibitory activity against the neuronal isozyme of nitric oxide synthase.
Reversal of multidrug resistance in human carcinoma cell line by agosterols, marine spongean sterols
Shunji Aoki,Andi Setiawan,Yasuhiro Yoshioka,Kouichi Higuchi,Ritsuko Fudetani,Zhe-Sheng Chen,Tomoyuki Sumizawa,Shin-ichi Akiyama,Motomasa Kobayashi +8 more
TL;DR: From the structure-activity relationship study, each of the 3,4,6-acetoxyl groups and 11,22-hydroxyl groups was elucidated to be crucial for reversing MDR in tumor cells.
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Marine Natural Products. XXXVII. Aragusteroketals A and C, Tow Novel Cytotoxic Steroids from a Marine Sponge of Xestospongia sp.
TL;DR: Aragusteroketals A (1) and C (2) as mentioned in this paper, two marine steroids having dimethylketal structure, were isolated from an Okinawan marine sponge of Xestospongia sp. The chemical structures of 1 and 2 were determined on the basis of spectroscopic analysis and chemical evidence.
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Myrmekiosides a and b, novel mono-o-alkyl-diglycosylglycerols reversing tumor cell morphology of ras-transformed cells from a marine sponge of myrmekioderma sp
TL;DR: In this paper, a novel mono-O -alkyl-diglycosylglycerols named myrmekiosides A ( 1 ) and B ( 2 ) were isolated from a marine sponge of Myrmekioderma sp. and their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence.
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Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene.
Shunji Aoki,Kouichi Higuchi,Nahoko Isozumi,Kouhei Matsui,Yasuhisa Miyamoto,Norio Itoh,Keiichi Tanaka,Motomasa Kobayashi +7 more
TL;DR: Scalarane-type sesterterpenes, PHC-1-PHC-7, which have been isolated from a marine sponge, increased hemoglobin production in human chronic myelogenous leukemia cell line K562 at the concentration of 0.1-5 microg/ml and were found to induce erythroid differentiation in K562 cells.
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