Kosuke Yasuda
Mitsubishi Tanabe Pharma
19 Papers
346 Citations
Kosuke Yasuda is an academic researcher from Mitsubishi Tanabe Pharma. The author has contributed to research in topics: Glucokinase & Alkyl. The author has an hindex of 9, co-authored 19 publications.
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Papers
Patent
Tri(cyclo) substituted amide compounds
Matthew Colin Thor Fyfe,Lisa Sarah Gardner,Maseo Nawano,Martin James Procter,Chrystelle Marie Rasamison,Karen Lesley Schofield,Vilasben Kanji Shah,Kosuke Yasuda +7 more
- 10 Feb 2004
TL;DR: In this article, the authors used compound of formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
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Patent
Tri(cyclo) substituted amide glucokinase activator compounds
Matthew Colin Thor Fyfe,Lisa Sarah Gardner,Masao Nawano,Martin James Procter,Geoffrey Martyn Williams,David J. Witter,Kosuke Yasuda,Chrystelle Marie Rasamison,Castelhano Arlindo L +8 more
- 10 Feb 2004
TL;DR: In this article, the authors present a list of compounds of formula (I): (I) or pharmaceutically acceptable salts or Noxides thereof, which are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
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Glucokinase-activating ureas.
Arlindo L. Castelhano,Hanqing Dong,Matthew C. T. Fyfe,Lisa Sarah Gardner,Yukari Kamikozawa,Satomi Kurabayashi,Masao Nawano,Rikiya Ohashi,Martin James Procter,Li Qiu,Chrystelle Marie Rasamison,Karen Lesley Schofield,Vilas K. Shah,Kiichiro Ueta,Geoffrey Martyn Williams,David J. Witter,Kosuke Yasuda +16 more
TL;DR: The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described.
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SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides: discovery of PSN-GK1.
Lisa Sarah Bertram,Daniel Black,Paul H. Briner,Rosemary Chatfield,Andrew Cooke,Matthew Colin Thor Fyfe,P. John Murray,Frédéric Naud,Masao Nawano,Martin James Procter,Günaj Rakipovski,Chrystelle Marie Rasamison,Christine Reynet,Karen Lesley Schofield,Vilas K. Shah,Felix Spindler,Amanda Taylor,Roy Turton,Geoffrey Martyn Williams,Philippe Wong-Kai-In,Kosuke Yasuda +20 more
TL;DR: The optimization of a weakly active high-throughput screening hit to PSN-GK1, a potent GK activator with an improved pharmacokinetic and safety profile, elicited robust glucose lowering in rats.
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Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.
Kenji Arakawa,Masanori Inamasu,Mamoru Matsumoto,Kunihito Okumura,Kosuke Yasuda,Hidenori Akatsuka,Saburo Kawanami,Akishige Watanabe,Koichi Homma,Yutaka Saiga,Masakatsu Ozeki,Ikuo Iijima +11 more
TL;DR: 2-Arylmethyl- and 2-(heteroarylmethyl)benzoxazole derivatives showed far more potent activity than known 2,4-thiazolidinedione derivatives such as ciglitazone, troglitaz one and pioglitazOne in evaluating hypoglycemic activity in genetically obese and diabetic yellow KK mice.
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