Purpose: Prior to 90 Y radioembolization procedure a pretherapy simulation using 99m Tc-MAA 23 is performed. Alternatively, a small dosage of 90 Y microspheres could be used. We aimed to 24 assess the accuracy of lung shunt fraction (LSF) estimation in both high activity 90 Y 25 posttreatment and pretreatment scans with isotope activity of ~100 MBq, using different 26 imaging techniques. Additionally, we assessed the feasibility of visualising hot and cold 27 hepatic tumours in PET/CT and Bremsstrahlung SPECT/CT images. 28 Materials and Methods: Anthropomorphic phantom including liver (with two spherical 29 tumours) and lung inserts was filled with 90 Y chloride to simulate an LSF of 9.8%. The total 30 initial activity in the liver was 1451 MBq, including 19.4 MBq in the hot sphere. Nine 31 measurement sessions including PET/CT, SPECT/CT, and planar images were acquired at 32 activities in the whole phantom ranging from 1618 MBq down to 43 MBq. The visibility scores.

PET/CT and SPECT/CT imaging of 90 Y hepatic radioembolization at 2 therapeutic and diagnostic activity levels: anthropomorphic phantom study and SPECT/CT anthropomorphic phantom imaging

22 Purpose: Prior to 90 Y radioembolization procedure a pretherapy simulation using 99m Tc-MAA 23 is performed. Alternatively, a small dosage of 90 Y microspheres could be used. We aimed to 24 assess the accuracy of lung shunt fraction (LSF) estimation in both high activity 90 Y 25 posttreatment and pretreatment scans with isotope activity of ~100 MBq, using different 26 imaging techniques. Additionally, we assessed the feasibility of visualising hot and cold 27 hepatic tumours in PET/CT and Bremsstrahlung SPECT/CT images. 28 Materials and Methods: Anthropomorphic phantom including liver (with two spherical 29 tumours) and lung inserts was filled with 90 Y chloride to simulate an LSF of 9.8%. The total 30 initial activity in the liver was 1451 MBq, including 19.4 MBq in the hot sphere. Nine 31 measurement sessions including PET/CT, SPECT/CT, and planar images were acquired at 32 activities in the whole phantom ranging from 1618 MBq down to 43 MBq.

PET/CT and SPECT/CT imaging of 90 Y hepatic radioembolization at

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PET/CT and SPECT/CT imaging of 90 Y hepatic radioembolization at 2 therapeutic and diagnostic activity levels: anthropomorphic phantom study and SPECT/CT anthropomorphic phantom imaging

PET/CT and SPECT/CT imaging of 90 Y hepatic radioembolization at