Kojiro Yae
Keio University
7 Papers
26 Citations
Kojiro Yae is an academic researcher from Keio University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 6, co-authored 7 publications.
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Papers
Generation of Induced Pluripotent Stem Cells from Human Terminally Differentiated Circulating T Cells
Tomohisa Seki,Shinsuke Yuasa,Mayumi Oda,Toru Egashira,Kojiro Yae,Dai Kusumoto,Hikari Nakata,Shugo Tohyama,Hisayuki Hashimoto,Masaki Kodaira,Yohei Okada,Hiroyuki Seimiya,Noemi Fusaki,Mamoru Hasegawa,Keiichi Fukuda +14 more
TL;DR: A manuscript has appeared online demonstrating isolation of iPSCs from peripheral blood, including a single line that showed evidence for both T CR-β and TCR-γ rearrangement by PCR.
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Generation and Characterization of Functional Cardiomyocytes Derived from Human T Cell-Derived Induced Pluripotent Stem Cells
Tomohisa Seki,Shinsuke Yuasa,Dai Kusumoto,Akira Kunitomi,Yuki Saito,Shugo Tohyama,Kojiro Yae,Yoshikazu Kishino,Marina Okada,Hisayuki Hashimoto,Makoto Takei,Toru Egashira,Masaki Kodaira,Yusuke Kuroda,Atsushi Tanaka,Shinichiro Okata,Tomoyuki Suzuki,Mitsushige Murata,Jun Fujita,Keiichi Fukuda +19 more
TL;DR: It is shown that TiPSCs successfully differentiated into cardiomyocytes with morphology, gene expression patterns, and electrophysiological features typical of native cardiomeocytes, which could become disease models for understanding the mechanisms of cardiac disease and cell sources for revolutionaryCardiomyocyte therapies.
Distinct iPS Cells Show Different Cardiac Differentiation Efficiency
Yohei Ohno,Shinsuke Yuasa,Toru Egashira,Tomohisa Seki,Hisayuki Hashimoto,Shugo Tohyama,Yuki Saito,Akira Kunitomi,Kenichiro Shimoji,Takeshi Onizuka,Toshimi Kageyama,Kojiro Yae,Tomofumi Tanaka,Ruri Kaneda,Fumiyuki Hattori,Mitsushige Murata,Kensuke Kimura,Keiichi Fukuda +17 more
TL;DR: Assessment of the differentiation potential, time course, and efficiency of different types of iPS cell lines to differentiate into cardiomyocytes in vitro found that high-quality iPS cells exhibited betterCardiomyocyte differentiation in terms of the time course and Efficiency of differentiation than low-qualityiPS cells, which hardly ever differentiated into carduomyocytes.
•Journal Article
Abstract 2296: Generation of Induced Pluripotent Stem Cells in Healthy Volunteers and Patients With Hereditary Heart Disease
Toru Egashira,Shinsuke Yuasa,Yohei Ohno,Tomohisa Seki,Hisayuki Hashimoto,Shogo Toyama,Sung H Yoon,Chen Hao,Tomofumi Tanaka,Fumiyuki Hattori,Kojiro Yae,Mitsushige Murata,Satoshi Ogawa,Keiichi Fukuda +13 more
TL;DR: It is reported that human induced pluripotent stem cells can be induced to differentiate into cardiomyocytes, and the phenotype of these cells is characterized.
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G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs.
Kenichiro Shimoji,Shinsuke Yuasa,Takeshi Onizuka,Fumiyuki Hattori,Tomofumi Tanaka,Mie Hara,Yohei Ohno,Hao Chen,Toru Egasgira,Tomohisa Seki,Kojiro Yae,Uichi Koshimizu,Satoshi Ogawa,Keiichi Fukuda +13 more
TL;DR: It is indicated that G-CSF is critically involved in cardiomyocyte proliferation during development, and may be used to boost the yield of cardiomeocytes from ESCs for their potential application to regenerative medicine.