Koji Isozaki
Hyogo College of Medicine
47 Papers
467 Citations
Koji Isozaki is an academic researcher from Hyogo College of Medicine. The author has contributed to research in topics: Gene mutation & Interstitial cell of Cajal. The author has an hindex of 27, co-authored 45 publications. Previous affiliations of Koji Isozaki include Osaka University.
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Papers
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Seiichi Hirota,Koji Isozaki,Yasuhiro Moriyama,Koji Hashimoto,Toshirou Nishida,Shingo Ishiguro,Kiyoshi Kawano,Masato Hanada,Akihiko Kurata,Masashi Takeda,Ghulam Muhammad Tunio,Yuji Matsuzawa,Yuzuru Kanakura,Yasuhisa Shinomura,Yukihiko Kitamura +14 more
TL;DR: Sequencing of c-kit complementary DNA from five GISTs revealed mutations in the region between the transmembrane and tyrosine kinase domains, suggesting that the mutations contribute to tumor development.
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A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors
Masanori Nakahara,Koji Isozaki,Seiichi Hirota,Jun-ichiro Miyagawa,Naoko Hase-Sawada,Masahiko Taniguchi,Toshirou Nishida,Suji Kanayama,Yukihiko Kitamura,Yasuhisa Shinomura,Yuji Matsuzawa +10 more
TL;DR: This study transfected mutant c-kit cDNA into an interleukin 3-dependent Ba/F3 murine lymphoid cell line, and the magnitude of autophosphorylation of the mutant KIT was examined with or without stem cell factor, a ligand of KIT.
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Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene.
Seiichi Hirota,Toshirou Nishida,Koji Isozaki,Masahiko Taniguchi,Kazuhiro Nishikawa,Akiko Ohashi,Arimichi Takabayashi,Tadashi Obayashi,Tomoko Okuno,Kazuo Kinoshita,Hui Chen,Yasuhisa Shinomura,Yukihiko Kitamura +12 more
TL;DR: This is the first report of familial dysphagia caused by germline gain-of-function mutation of the KIT gene at the TK II domain, found in a family with multiple gastrointestinal stromal tumors.
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Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats.
Koji Isozaki,Seiichi Hirota,Akihiro Nakama,Jun-ichiro Miyagawa,Yasuhisa Shinomura,Zude Xu,Shintaro Nomura,Yukihiko Kitamura +7 more
TL;DR: The abnormalities in the ileal movement and pyloric sphincter function in Ws/Ws rats were attributable to the deficiency of c-kit messenger RNA-expressing cells.
181
c‐kit Gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors
Kazuo Kinoshita,Koji Isozaki,Seiichi Hirota,Toshirou Nishida,Hui Chen,Masanori Nakahara,Yutaka Nagasawa,Akiko Ohashi,Yasuhisa Shinomura,Yukihiko Kitamura,Yuji Matsuzawa +10 more
TL;DR: The mutation at exon 17 observed in the familial GIST was detectable by the use of direct sequencing but not by the SSCP method, which was previously reported to be not detected by single‐strand conformation polymorphism (SSCP) analysis.
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