Koen Veys
Katholieke Universiteit Leuven
24 Papers
102 Citations
Koen Veys is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Chemistry & Angiogenesis. The author has an hindex of 11, co-authored 17 publications.
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Papers
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.
Gommaar D'Hulst,Inés Soro-Arnaiz,Evi Masschelein,Koen Veys,Gillian Fitzgerald,Benoit Smeuninx,Sunghoon Kim,Louise Deldicque,Bert Blaauw,Peter Carmeliet,Leigh Breen,Peppi Koivunen,Shimin Zhao,Shimin Zhao,Katrien De Bock +14 more
TL;DR: The authors show that the PHD1 controls muscle mass in a hydroxylation-independent manner and prevents the degradation of leucine sensor LRS during oxygen and amino acid depletion to ensure effective mTORC1 activation in response to leucines.
Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Joanna Kalucka,Laura P.M.H. de Rooij,Jermaine Goveia,Katerina Rohlenova,Sébastien J. Dumas,Elda Meta,Nadine V. Conchinha,Federico Taverna,Laure-Anne Teuwen,Koen Veys,Melissa García-Caballero,Shawez Khan,Vincent Geldhof,Liliana Sokol,Rongyuan Chen,Lucas Treps,Mila Borri,Pauline de Zeeuw,Charlotte Dubois,Tobias K. Karakach,Kim D. Falkenberg,Magdalena Parys,Xiangke Yin,Stefan Vinckier,Yuxiang Du,Robert A. Fenton,Luc Schoonjans,Luc Schoonjans,Mieke Dewerchin,Guy Eelen,Bernard Thienpont,Lin Lin,Lars Bolund,Xuri Li,Yonglun Luo,Peter Carmeliet,Peter Carmeliet +36 more
TL;DR: An atlas of >32,000 single-EC transcriptomes from 11 mouse tissues was constructed and 78 EC subclusters were identified, including Aqp7+ intestinal capillaries and angiogenic ECs in healthy tissues and provides a powerful discovery tool and resource value.
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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
Anna Rita Cantelmo,Lena Christin Conradi,Aleksandra Brajic,Jermaine Goveia,Joanna Kalucka,Andreas Pircher,Pallavi Chaturvedi,Johanna Hol,Bernard Thienpont,Laure Anne Teuwen,Sandra Schoors,Bram Boeckx,Joris Vriens,Anna Kuchnio,Koen Veys,Bert Cruys,Lise Finotto,Lucas Treps,Tor Espen Stav-Noraas,Francesco Bifari,Peter C. Stapor,Ilaria Decimo,Kim R. Kampen,Katrien De Bock,Guttorm Haraldsen,Luc Schoonjans,Ton J. Rabelink,Guy Eelen,Bart Ghesquière,Jalees Rehman,Diether Lambrechts,Asrar B. Malik,Mieke Dewerchin,Peter Carmeliet +33 more
TL;DR: It is shown that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis, which reduces cancer cell invasion, intravasation, and metastasis by normalizing tumor vessels by PFKFB3-blockade treatment, which improved vessel maturation and perfusion.
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Endothelial Cell Metabolism in Health and Disease
TL;DR: The most recent insights into EC metabolism in health and disease are discussed, with emphasis on the changes in metabolism in the tumor endothelium.
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Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis
Stefan Christen,Doriane Lorendeau,Roberta Schmieder,Dorien Broekaert,Kristine Metzger,Koen Veys,Ilaria Elia,Joerg Martin Buescher,Martin F. Orth,Shawn M. Davidson,Thomas G. P. Grunewald,Katrien De Bock,Sarah-Maria Fendt +12 more
TL;DR: In this paper, the authors measured PC-dependent anaplerosis in breast-cancer-derived lung metastases compared to their primary cancers using in-vivo 13C tracer analysis.
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