Klaus Schulten

TL;DR: Dramatic increases in computational power, in synergy with more efficient computational methodologies, now allow us to carry out molecular dynamics simulations of any structurally known membrane protein in its native environment, covering timescales of up to 0.1 micros.

TL;DR: A set of essential residues coevolutionarily coupled in related helicases that should be involved in the allosteric regulation of these motor proteins are identified.

TL;DR: It is shown that detection and localization of DNA methylation can be achieved with nanopore sensors made of two-dimensional materials such as graphene and molybdenum di-sulfide, thereby paving the way towards fast and low-cost DNA sequencing techniques for personal medicine.

TL;DR: A structural model of YidC based on evolutionary co-variation analysis, lipid-versus-protein-exposure and molecular dynamics simulations suggests a distinctive arrangement of the conserved five transmembrane domains and a helical hairpin between trans Membrane segment 2 (TM2) and TM3 on the cytoplasmic membrane surface.