Klaus H. Metzeler
Ludwig Maximilian University of Munich
219 Papers
487 Citations
Klaus H. Metzeler is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Myeloid leukemia & Medicine. The author has an hindex of 44, co-authored 156 publications. Previous affiliations of Klaus H. Metzeler include German Cancer Research Center & Roswell Park Cancer Institute.
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Papers
Prognostic impact of the AML ELN2022 risk classification in patients undergoing allogeneic stem cell transplantation
Madlen Jentzsch,L. Bischof,J. Ussmann,Donata Backhaus,Dominic Brauer,Klaus H. Metzeler,Maximilian Merz,Vladan Vucinic,Georg-Nikolaus Franke,Marco Herling,Uwe Platzbecker,Sebastian Schwind +11 more
TL;DR: In this paper , the authors retrospectively analyzed 522 acute myeloid leukemia (AML) patients who received an allogeneic hematopoietic stem cell transplantation (HSCT) at a median age of 59 (range 16-76) years.
Clonal hematopoiesis and preleukemia-Genetics, biology, and clinical implications.
Luise Hartmann,Klaus H. Metzeler +1 more
TL;DR: The current knowledge on CH as a precursor of myeloid cancers and the implications of CH‐related gene mutations in the diagnostic workup of patients with suspected myelodysplastic syndrome are summarized.
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia
Klaus H. Metzeler,Klaus H. Metzeler,Tobias Herold,Tobias Herold,Maja Rothenberg-Thurley,Susanne Amler,Maria Cristina Sauerland,Dennis Görlich,Stephanie Schneider,Nikola P. Konstandin,Annika Dufour,Kathrin Bräundl,Kathrin Bräundl,Bianka Ksienzyk,Evelyn Zellmeier,Luise Hartmann,Luise Hartmann,Philipp A. Greif,Philipp A. Greif,Michael Fiegl,Marion Subklewe,Marion Subklewe,Stefan K. Bohlander,Utz Krug,Andreas Faldum,Wolfgang E. Berdel,Bernhard Wörmann,Thomas Büchner,Wolfgang Hiddemann,Wolfgang Hiddemann,Jan Braess,Karsten Spiekermann,Karsten Spiekermann +32 more
TL;DR: This study provides a comprehensive overview of the spectrum, clinical associations, and prognostic relevance of recurrent driver gene mutations in a large cohort representing a broad spectrum and age range of intensively treated AML patients.
Clonal hematopoiesis of indeterminate potential in older patients having received an allogeneic stem cell transplantation from young donors.
Anezka Heumüller,Julius Wehrle,Juliane M. Stosch,Christoph Niemöller,Sabine Bleul,Miguel Waterhouse,David Uhl,Klaus H. Metzeler,Michael Lübbert,Justus Duyster,Jürgen Finke,Heiko Becker +11 more
TL;DR: Whether older patients who had received HSCT from a young donor frequently develop CHIP is examined, to suggest hematopoietic cellextrinsic processes that are particularly beneficial for the induction or selection of CHIP.
Association between a prognostic gene signature and functional gene sets.
TL;DR: The strategies proposed in this paper go beyond the restriction of annotation and deepen the insights into the biological mechanisms reflected in the information given by a signature, as demonstrated in the example of cancer-related pathways.