Klarke M. Sample
Guizhou University
8 Papers
22 Citations
Klarke M. Sample is an academic researcher from Guizhou University. The author has contributed to research in topics: MAPK/ERK pathway & Gene silencing. The author has an hindex of 3, co-authored 8 publications.
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Papers
Erythropoietin Signaling in the Microenvironment of Tumors and Healthy Tissues
Wuling Liu,Wuling Liu,Krishnapriya Madhu Varier,Klarke M. Sample,Eldad Zacksenhaus,Eldad Zacksenhaus,Babu Gajendran,Babu Gajendran,Yaacov Ben-David,Yaacov Ben-David +9 more
TL;DR: In this chapter, in addition to the clinical relevance of EPO/EPOR signaling, its anticancer efficacy within various tumor microenvironments is reviewed.
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ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional stimulation of cholesterol biosynthesis genes.
Fang Yu,Babu Gajendran,Ning Wang,Klarke M. Sample,Wuling Liu,Chunlin Wang,Anling Hu,Eldad Zacksenhaus,Eldad Zacksenhaus,Xiao-Jiang Hao,Yaacov Ben-David +10 more
TL;DR: In this paper, the authors investigated the downstream consequences of these ERK/MAPK agonists in leukemic cells and found that activation of SREBP1/2 by A1542-A1543 was responsible for induction of only a subset of cholesterol genes.
A C21-steroidal derivative suppresses T-cell lymphoma in mice by inhibiting SIRT3 via SAP18-SIN3.
Babu Gajendran,Krishnapriya Madhu Varier,Wuling Liu,Chunlin Wang,Klarke M. Sample,Eldad Zacksenhaus,Eldad Zacksenhaus,Cui Juiwei,Lie-Jun Huang,Xiao-Jiang Hao,Yaacov Ben-David +10 more
- 03 Dec 2020
TL;DR: The identification of a C 21 -steroidal derivative compound, A671, which potently suppresses the growth of mouse and human T-cell lymphoma and erythroleukemia in vitro and preclinical models and finds that A671 activates SAP18 to suppress the transcription of SIRT3, inhibiting cell growth.
FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.
Chunlin Wang,Jialei Song,Wuling Liu,Yao Yao,Philipp Kapranov,Klarke M. Sample,Babu Gajendran,Eldad Zacksenhaus,Xiao-Jiang Hao,Yaacov Ben‑David +9 more
TL;DR: A critical role for FLI1 is uncovered in the control of protein translation and the importance of targeting its function and downstream mediators, such as MKNK1, for cancer therapy is uncovered.
Ubash3b promotes TPA-mediated suppression of leukemogenesis through accelerated downregulation of PKCδ protein.
Yao Yao,Wuling Liu,Babu Gajendran,Chunlin Wang,Eldad Zacksenhaus,Klarke M. Sample,Krishnapriya Madhu Varier,Xiao-Jiang Hao,Yaacov Ben-David +8 more
TL;DR: In this paper, a combination of TPA and the proteasome inhibitor ALLN significantly suppressed leukemia in a mouse model of leukemia and showed that PKCδ downregulation by TPA was independent of the downstream MAPK/ERK/P38/JNK pathway.
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