Kiyoshi Zaitsu
Kyushu University
147 Papers
1.2K Citations
Kiyoshi Zaitsu is an academic researcher from Kyushu University. The author has contributed to research in topics: Chemiluminescence & High-performance liquid chromatography. The author has an hindex of 26, co-authored 147 publications.
Chat about Author
Papers
D-Amino acids in mammals and their diagnostic value.
TL;DR: In this article, analytical methods including chromatographic, electrophoretic and enzymatic methods to determine D-amino acids in mammalian tissues are reviewed, and the distribution of these DAMINO acids in mammals is discussed.
205
New fluorogenic substrates for horseradish peroxidase: rapid and sensitive assays for hydrogen peroxide and the peroxidase.
Kiyoshi Zaitsu,Yosuke Ohkura +1 more
TL;DR: A very rapid and sensitive method for the fluorometric assays of hydrogen peroxide and the peroxidase was established by using 3-( p -hydroxyphenyl)propionic acid as the best of these substrates.
201
Determination of free D-aspartic acid, D-serine and D-alanine in the brain of mutant mice lacking D-amino acid oxidase activity.
TL;DR: A simple and precise method for the simultaneous determination of free D-aspartic acid, D-serine and D-alanine in mouse brain tissues was established, using a reversed-phase HPLC system with widely used pre-column derivatizing reagents, o-phthaldialdehyde and N-t-butyloxycarbonyl-L-cysteine.
144
Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection.
TL;DR: The present micro-2D-HPLC procedures are powerful tools for the determination of small amounts of D-Ser and D-Ala in mammalian samples, and the obtained results would be useful for developing novel drugs that modulate the DAO activity, such as DAO inhibitors, against neuronal diseases.
143
Brain-specific Phgdh Deletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, an N-methyl-d-aspartate Receptor Co-agonist, in Adult Brain
Jung Hoon Yang,Akira Wada,Kazuyuki Yoshida,Kazuyuki Yoshida,Yurika Miyoshi,Tomoko Sayano,Kayoko Esaki,Masami O. Kinoshita,Masami O. Kinoshita,Shozo Tomonaga,Norihiro Azuma,Masahiko Watanabe,Kenji Hamase,Kiyoshi Zaitsu,Takeo Machida,Albee Messing,Shigeyoshi Itohara,Yoshio Hirabayashi,Shigeki Furuya,Shigeki Furuya +19 more
TL;DR: It is provided definitive proof that l-serine-synthesized endogenously via the phosphorylated pathway is a key rate-limiting factor for maintaining steady-state levels of d-Serine in adult brain.
129