Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure 1/28th the area of the starting gel in 24 hr. The rate of the process can be regulated by varying the protein content of the lattice, the cell number, or the con- centration of an inhibitor such as Colcemid. Fibroblasts of high population doubling level propagated in vitro, which have left the cell cycle, can carry out the contraction at least as efficiently as cycling cells. The potential uses of the system as an immu- nologically tolerated "tissue" for wound hea ing and as a model for studying fibroblast function are discussed.

Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative

Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

/pdf/polymeric-scaffolds-in-tissue-engineering-application-a-2sbenjc1po.pdf

Polymeric scaffolds in tissue engineering application: a review

https://repositorium.sdum.uminho.pt/bitstream/1822/14053/1/file.pdf

Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications

http://www.bio21.bas.bg/ibf/PC_review.pdf

Phases and phase transitions of the phosphatidylcholines

Dimeric and oligomeric surfactants. Behavior at interfaces and in aqueous solution: a review.

Triallyl phosphate alkylated uracil (N-1), thymine (N-1), cytosine (N-1), adenine (N-3 and N-9), and guanine (presumably N-1 or N-7) in a water solution at 60 °C (pH values were 10–10.5 for uracil, thymine, cytosine, and adenine, and 12 for guanine), giving the corresponding allyl derivatives in considerable yields.

Allylation of nucleic acid bases with triallyl phosphate

Archaebacterial lipids are featured by C20-, C25-and C40-polyisoprenoid chains connected to a glycerol moiety by an ether linkage. The polyisoprenoid lipids including model compounds gave rise to double layer, unilayer and Q phase-like membranes. The morphology depended strongly on the structure of the lipids. The liposomal membranes made of the polyisoprenoid lipids were very stable at high temperature without undergoing morphological perturbation. The membranes were highly resistant to permeation of protons and various organic compounds as well as inorganic salts. It was also found that the surface energy of the molecular assemblies were extraordinally low, some approaching to the value of fluorocabon materials. These properties and functions were explained by fluidity of each polyisoprenoid chain and rigidity of an polyisoprenoid chain-array in the membranes.

https://www.jstage.jst.go.jp/article/jos1996/46/5/46_5_539/_pdf

Structure and Functions of Archaebacterial Lipid Membranes

Chemical synthesis of barnase which possesses phosphoserine residue in place of the catalytic glutamic acid at position 73

Vinyl-polymerisation 272. mitt. synth. und polymerisation von 9-0-methacryloylchinin

Die Reaktion des mit P-tribromid aus seinem Alkohol erhaltenen Bromids (I) mit Triathylphosphit fuhrt zum Aminophosphonsaureester (IIa).

Aminophosphonsaeure enthaltende peptide 2. mitt. synth. von tripeptid-analogen

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