Kirthan Shenoy
National University of Singapore
3 Papers
77 Citations
Kirthan Shenoy is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & Mitogen-activated protein kinase. The author has an hindex of 3, co-authored 3 publications.
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Papers
Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells
Resham L Gurung,Shi Ni Lim,Aik Kia Khaw,Jasmine Fen Fen Soon,Kirthan Shenoy,Safiyya Mohamed Ali,Manikandan Jayapal,Swaminathan Sethu,Rajamanickam Baskar,M. Prakash Hande +9 more
TL;DR: Thymoquinone could be useful as a potential chemotherapeutic agent in the management for brain tumours and induces DNA damage, telomere attrition by inhibiting telomerase and cell death in glioblastoma cells.
TRAILing death in cancer.
TL;DR: An overview of the biology, function and translational relevance of TRAIL is presented with a specific view to discussing the various regulatory mechanisms and the current trends in reverting TRAIL resistance of cancer cells with the obvious implication of an improved clinical outcome.
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LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide–Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors
TL;DR: Data show that JNK and ERK are two crucial players involved in H(2)O(2)-mediated increase in TRAIL sensitization of tumor cells upon exposure to LY30 and underscore a novel mode of action of this inactive analogue of LY29.
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