Kirsi H. Pietiläinen
University of Helsinki
281 Papers
3.7K Citations
Kirsi H. Pietiläinen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Adipose tissue. The author has an hindex of 65, co-authored 235 publications. Previous affiliations of Kirsi H. Pietiläinen include Helsinki University Central Hospital & University of Oulu.
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Papers
Liver Fat in the Metabolic Syndrome
TL;DR: Liver fat content is significantly increased in subjects with the metabolic syndrome as compared with those without the syndrome, independently of age, gender, and body mass index.
483
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
Johannes Kettunen,Taru Tukiainen,Antti-Pekka Sarin,Alfredo Ortega-Alonso,Emmi Tikkanen,Leo-Pekka Lyytikäinen,Antti J. Kangas,Pasi Soininen,Peter Wuertz,Kaisa Silander,Danielle M. Dick,Richard J. Rose,Markku J. Savolainen,Jorma Viikari,Mika Kähönen,Terho Lehtimäki,Kirsi H. Pietiläinen,Michael Inouye,Mark I. McCarthy,Antti Jula,Johan G. Eriksson,Olli T. Raitakari,Veikko Salomaa,Jaakko Kaprio,Marjo-Riitta Järvelin,Leena Peltonen,Markus Perola,Nelson B. Freimer,Mika Ala-Korpela,Aarno Palotie,Samuli Ripatti +30 more
- 01 Jan 2012
459
Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects - A monozygotic twin study
Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Marko Sysi-Aho,Aila Rissanen,Tuulikki Seppänen-Laakso,Hannele Yki-Järvinen,Jaakko Kaprio,Matej Orešič +7 more
TL;DR: Results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.
FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study.
Anu Suomalainen,Anu Suomalainen,Jenni M. Elo,Kirsi H. Pietiläinen,Anna H. Hakonen,Ksenia Sevastianova,Mari Päivikki Korpela,Pirjo Isohanni,Pirjo Isohanni,Sanna Marjavaara,Tiina Tyni,Tiina Tyni,Sari Kiuru-Enari,Helena Pihko,Niklas Darin,Katrin Õunap,Leo A. J. Kluijtmans,Anders Paetau,Jana Buzkova,Laurence A. Bindoff,Johanna Annunen-Rasila,Johanna Uusimaa,Aila Rissanen,Hannele Yki-Järvinen,Michio Hirano,Mar Tulinius,Jan A.M. Smeitink,Henna Tyynismaa +27 more
TL;DR: Measurement of FGF-21 concentrations in serum identified primary muscle-manifesting respiratory chain deficiencies in adults and children and might be feasible as a first-line diagnostic test for these disorders to reduce the need for muscle biopsy.
419
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans
Adil Mardinoglu,Hao Wu,Elias Björnson,Cheng Zhang,Antti Hakkarainen,Sari M. Räsänen,Sunjae Lee,Rosellina Margherita Mancina,Mattias Bergentall,Kirsi H. Pietiläinen,Sanni Söderlund,Niina Matikainen,Marcus Ståhlman,Per Olof Bergh,Martin Adiels,Brian D. Piening,Marit Granér,Nina Lundbom,Kevin Jon Williams,Stefano Romeo,Jens Nielsen,Michael Snyder,Mathias Uhlén,Göran Bergström,Rosie Perkins,Hanns-Ulrich Marschall,Fredrik Bäckhed,Marja-Riitta Taskinen,Jan Borén +28 more
TL;DR: A short-term intervention with an isocaloric low-carbohydrate diet with increased protein content in obese subjects with NAFLD and the resulting alterations in metabolism and the gut microbiota are characterized using a multi-omics approach to highlight the potential of exploring diet-microbiota interactions for treatingNAFLD.
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