Kirk Arvidson
Center for Food Safety and Applied Nutrition
20 Papers
189 Citations
Kirk Arvidson is an academic researcher from Center for Food Safety and Applied Nutrition. The author has contributed to research in topics: Computer science & Adverse Outcome Pathway. The author has an hindex of 13, co-authored 19 publications. Previous affiliations of Kirk Arvidson include Food and Drug Administration.
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Papers
New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling.
Chihae Yang,Aleksey Tarkhov,J. Marusczyk,Bruno Bienfait,Johann Gasteiger,Thomas Kleinoeder,Tomasz Magdziarz,Oliver Sacher,Christof H. Schwab,Johannes Schwoebel,Lothar Terfloth,Kirk Arvidson,Ann M. Richard,Andrew Worth,James F. Rathman +14 more
TL;DR: The full specifications of the XML-based CSRML standard used to express chemotypes are publicly available to facilitate and encourage the exchange of structural knowledge.
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Thresholds of Toxicological Concern for cosmetics-related substances: New database, thresholds, and enrichment of chemical space.
Chihae Yang,Susan Barlow,Kristi L. Muldoon Jacobs,Vessela Vitcheva,Alan R. Boobis,Susan P. Felter,Kirk Arvidson,Detlef Keller,Mark T. D. Cronin,Steven J. Enoch,Andrew Worth,Heli M. Hollnagel +11 more
TL;DR: A new dataset of cosmetics-related chemicals for the Threshold of Toxicological Concern (TTC) approach has been compiled, comprising 552 chemicals with 219, 40, and 293 chemicals in Cramer Classes I, II, and III, respectively.
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Pathways of Toxicity.
Andre Kleensang,Alexandra Maertens,Michael Rosenberg,Suzanne Fitzpatrick,Justin Lamb,Scott S. Auerbach,Richard J. Brennan,Kevin M. Crofton,Ben Gordon,Albert J. Fornace,Kevin W. Gaido,David Gerhold,Robin Haw,Adriano Henney,Avi Ma'ayan,Mary McBride,Stefano Monti,Michael F. Ochs,Akhilesh Pandey,Roded Sharan,Rob H. Stierum,Stuart Tugendreich,Catherine Willett,Clemens Wittwehr,Jianguo Xia,Geoffrey W. Patton,Kirk Arvidson,Mounir Bouhifd,Helena T. Hogberg,Thomas Luechtefeld,Lena Smirnova,Liang Zhao,Yeyejide Adeleye,Minoru Kanehisa,Paul L. Carmichael,Melvin E. Andersen,Thomas Hartung +36 more
TL;DR: The Pathways of Toxicity (PoT) as discussed by the authors is a molecular definition of cellular processes shown to mediate adverse outcomes of toxicants, and it is further recognized that normal physiological pathways exist that maintain homeostasis and these can become PoTs.
Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling
TL;DR: This study finds that the in silico QSAR analysis employing this software's rodent carcinogenicity database is capable of identifying the rodent carcinogenic potential of naturally occurring organic molecules found in the human diet with a high degree of sensitivity.
80
Understanding Genetic Toxicity Through Data Mining: The Process of Building Knowledge by Integrating Multiple Genetic Toxicity Databases
Chihae Yang,Catrin Hasselgren,Scott Boyer,Kirk Arvidson,S Aveston,P Dierkes,Romualdo Benigni,R D Benz,Joseph F. Contrera,Naomi L. Kruhlak,Edwin J. Matthews,X Han,J Jaworska,Raymond A. Kemper,James F. Rathman,Ann M. Richard +15 more
TL;DR: The usefulness of representing a chemical by its structural features and the use of these features to profile a battery of tests rather than relying on a single toxicity test of a given chemical is demonstrated.
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