Kimishige Ishizaka
Johns Hopkins University
256 Papers
7.9K Citations
Kimishige Ishizaka is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Immunoglobulin E & Antibody. The author has an hindex of 66, co-authored 256 publications. Previous affiliations of Kimishige Ishizaka include Rockefeller University.
Chat about Author
Papers
•Journal Article
Lymphocytes bearing Fc receptors for IgE. I. Presence of human and rat T lymphocytes with Fc epsilon receptors.
J Yodoi,Kimishige Ishizaka +1 more
TL;DR: Evidence was obtained that FceR on T cells are distinct from Fc receptors for IgG (FcγR), which were demonstrated by rosette formation with ox erythrocytes coated with rabbit IgG antibodies (EA).
175
Development of human mast cells in vitro.
Takuma Furitsu,Hirohisa Saito,Ann M. Dvorak,Lawrence B. Schwartz,Anne-Marie Irani,James F. Burdick,Kimishige Ishizaka,Teruko Ishizaka +7 more
TL;DR: Electron microscopic analysis showed that the cultured mast cells were mature human mast cells, clearly different from the basophilic granulocytes or eosinophils that arise in a variety of circumstances in cord blood cell cultures.
175
•Journal Article
Mechanisms of Passive Sensitization: III. Number of IgE Molecules and Their Receptor Sites on Human Basophil Granulocytes
TL;DR: The results indicated that even “non-acceptor” cells combined IgE antibody upon passive sensitization with reaginic serum and, therefore, that failure of antigen-induced histamine release from these cells was not due to lack of IgE antibodies on their surface.
171
Biologic function of the Fc fragments of E myeloma protein
TL;DR: The results suggested that structural changes in the Fc portion of γE molecules initiate enzymatic sequences leading to the release of the chemical mediators in E myeloma protein PS.
165
•Journal Article
Mechanisms of Passive Sensitization: IV. Dissociation of IgE Molecules from Basophil Receptors at Acid PH
TL;DR: The mononuclear cell fraction of human leukocytes was exposed to different pH at 0°C and the presence of cell-bound IgE molecules on basophil granulocytes was examined by autoradiography, indicating that the binding between IgE and receptor molecules was reversible and did not involve a covalent bond.
162