Kikuo Isoda
Juntendo University
125 Papers
427 Citations
Kikuo Isoda is an academic researcher from Juntendo University. The author has contributed to research in topics: Percutaneous coronary intervention & Coronary artery disease. The author has an hindex of 23, co-authored 114 publications. Previous affiliations of Kikuo Isoda include National Defense Medical College.
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Papers
Pressure-Mediated Hypertrophy and Mechanical Stretch Induces IL-1 Release and Subsequent IGF-1 Generation to Maintain Compensative Hypertrophy by Affecting Akt and JNK Pathways
Shoken Honsho,Susumu Nishikawa,Katsuya Amano,Kan Zen,Yasushi Adachi,Eigo Kishita,Akihiro Matsui,Asako Katsume,Shinichiro Yamaguchi,Kenichiro Nishikawa,Kikuo Isoda,David W. H. Riches,Satoaki Matoba,Mitsuhiko Okigaki,Hiroaki Matsubara +14 more
TL;DR: It is demonstrated for the first time that pressure-mediated hypertrophy and mechanical stretch generates a subinflammatory low level of IL-1&bgr;, which constitutively causes IGF-1 production to maintain adaptable compensation hypertropy and inhibit interstitial fibrosis.
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Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions
Kikuo Isoda,Yashuhiro Kamezawa,Makoto Ayaori,Masatoshi Kusuhara,Norihiro Tada,Fumitaka Ohsuzu +5 more
TL;DR: The expression of OPN induces fatty-streak lesion formation in mice fed an atherogenic diet and inhibits IL-10 production by macrophages, thus suggesting that OPN plays an important role in the development of fatty-Streak lesions in vivo.
106
Deficiency of Interleukin-1 Receptor Antagonist Promotes Neointimal Formation After Injury
Kikuo Isoda,Masaru Shiigai,Norio Ishigami,Taizo Matsuki,Reiko Horai,Kenichirou Nishikawa,Masatoshi Kusuhara,Yasuhiro Nishida,Yoichiro Iwakura,Fumitaka Ohsuzu +9 more
TL;DR: The results suggest that endogenous IL-1Ra may suppress other occlusive vascular responses to injury, such as atherosclerosis and restenosis after angioplasty.
99
Relationship between the prognostic nutritional index and long-term clinical outcomes in patients with stable coronary artery disease.
Hideki Wada,Tomotaka Dohi,Katsumi Miyauchi,Shitara Jun,Hirohisa Endo,Shinichiro Doi,Hirokazu Konishi,Ryo Naito,Shuta Tsuboi,Manabu Ogita,Takatoshi Kasai,Shinya Okazaki,Kikuo Isoda,Satoru Suwa,Hiroyuki Daida +14 more
TL;DR: The PNI was significantly associated with long-term cardiovascular outcomes in patients with stable CAD and may be useful for risk stratification of CAD patients undergoing elective PCI.
92
Prognostic impact of nutritional status assessed by the Controlling Nutritional Status score in patients with stable coronary artery disease undergoing percutaneous coronary intervention
Hideki Wada,Tomotaka Dohi,Katsumi Miyauchi,Shinichiro Doi,Hirokazu Konishi,Ryo Naito,Shuta Tsuboi,Manabu Ogita,Takatoshi Kasai,Shinya Okazaki,Kikuo Isoda,Satoru Suwa,Hiroyuki Daida +12 more
TL;DR: Nutritional status assessed by theCONUT score was significantly associated with long-term clinical outcomes in patients with CAD, and pre-PCI assessment of the CONUT score may provide useful prognostic information.
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