Khursheed Anwer
19 Papers
213 Citations
Khursheed Anwer is an academic researcher. The author has contributed to research in topics: Medicine & Gene delivery. The author has an hindex of 9, co-authored 11 publications.
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Papers
Biodistribution and gene expression of lipid/plasmid complexes after systemic administration
Ram I. Mahato,Khursheed Anwer,Frank Tagliaferri,Clare Meaney,Pat Leonard,Manpreet S. Wadhwa,Mark Logan,Martha French,Alain Rolland +8 more
TL;DR: A correlation between gene expression and cationic lipid:colipid ratios and lipid-to-plasmid charge ratio was also observed for DOTMA- and DolCE-based formulations, and DOLCE was found to be the most effective potentially biodegradable cATIONic lipid.
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Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle
Russell J. Mumper,Jijun Wang,Scott L. Klakamp,Hiro Nitta,Khursheed Anwer,Frank Tagliaferri,Alain Rolland +6 more
TL;DR: Up to a ten-fold enhancement in gene expression in rat muscle over the use of 'naked' DNA has been demonstrated using protective interactive noncondensing polymers developed to protect plasmids from extracellular nuclease degradation while allowing the flexible complex to diffuse throughout the muscle tissue.
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Synergistic effect of formulated plasmid and needle-free injection for genetic vaccines.
Khursheed Anwer,Keith A. Earle,Mei Shi,Jijun Wang,Russell J. Mumper,Belinda Proctor,Kimberly Jansa,Harry C. Ledebur,Stephen C. Davis,William H. Eaglstein,Alain Rolland +10 more
TL;DR: These data demonstrate that the combination of pDNA/ PVP complexes and a NFID act synergistically to achieve high and sustained levels of antigen-specific IgG response to expressed antigen, and may offer advantage over needle injection of naked DNA for the development of genetic vaccines.
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Cationic lipid-based delivery system for systemic cancer gene therapy.
Khursheed Anwer,Clare Meaney,Grace Kao,Nasir Hussain,Robert Shelvin,Rosa M. Earls,Pat Leonard,Abraham Quezada,Alain Rolland,Sean M. Sullivan +9 more
TL;DR: The vascularity of the tumor model is characterized, the in vivo gene transfer properties of the plasmid-based gene delivery system are characterized, and it is shown that the transgene expression level was sufficient to elicit a biological response by inhibiting tumor growth.
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Targeted gene delivery: a two-pronged approach.
TL;DR: This review will describe in detail the advances that have been made in each of the areas of gene targeting, including physical targeting and molecular biological targeting.
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