Kevin Melody
University of Texas Medical Branch
12 Papers
28 Citations
Kevin Melody is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Rilpivirine & Reverse transcriptase. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Kevin Melody include University of Pittsburgh & Louisiana State University.
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Papers
Establishment of an African green monkey model for COVID-19 and protection against re-infection.
Courtney Woolsey,Viktoriya Borisevich,Abhishek N. Prasad,Krystle N. Agans,Daniel J. Deer,Natalie S. Dobias,John C. Heymann,Stephanie L. Foster,Corri B. Levine,Liana Medina,Kevin Melody,Joan B. Geisbert,Karla A. Fenton,Thomas W. Geisbert,Robert W. Cross +14 more
TL;DR: It is reported that African green monkeys infected with the SARS-CoV-2 virus develop disease symptoms that closely resemble those seen in infected humans, making this animal model a useful surrogate to investigate immune responses to coronavirus infection.
Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants.
Steven J. Smith,Gary T. Pauly,Aamir Akram,Kevin Melody,Zandrea Ambrose,Joel P. Schneider,Stephen H. Hughes +6 more
TL;DR: It is shown that DOR is susceptible to a number of well-known NNRTI resistance mutations and an understanding of the mutational susceptibilities and binding interactions of NN RTIs with RT could be used to develop pairs of compounds with non-overlapping mutATIONAL susceptibilities.
Effectiveness of icing as a postharvest treatment for control of Vibrio vulnificus and Vibrio parahaemolyticus in the eastern oyster (Crassostrea virginica).
TL;DR: On-board and dockside icing did not predictably reduce the levels of V. vulnificus or V. parahaemolyticus in oysters, and icing negatively impacted oyster survival during subsequent cold storage.
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Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies.
Yash Agarwal,Cole Beatty,Shivkumar Biradar,Isabella Castronova,Sara Ho,Kevin Melody,Moses T. Bility +6 more
TL;DR: This review will discuss applications of HIS-humanized mouse models in evaluating the safety and efficacy of therapeutics against HIV reservoirs and associated immunopathology, and delineate the human immune response elicited by candidate HIV vaccines.
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Human immunodeficiency virus infection induces lymphoid fibrosis in the BM-liver-thymus-spleen humanized mouse model
Jasmine Samal,Samantha Kelly,Ali Na-Shatal,Abdallah Elhakiem,Antu Das,Ming Ding,Anwesha Sanyal,Phalguni Gupta,Kevin Melody,Brad Roland,Watfa Ahmed,Aala Zakir,Moses T. Bility +12 more
TL;DR: A potentially novel human immune system-humanized mouse model by coengrafting autologous fetal thymus, spleen, and liver organoids under the kidney capsule, thus termed the BM-liver-thymus-spleen (BLTS) humanized mice model, which will enable in vivo mechanistic studies and complementing the well-established surrogate model of SIV infection-induced lymphoid tissue fibrosis in macaques.